Kuz'min O B, Mikhaĭlenko P V
Farmakol Toksikol. 1987 Sep-Oct;50(5):39-42.
It was found in experiments on anesthetized rats that ethacrynic acid (3 mg/kg intravenously) exerted no effect on the blood flow in the internal zone of the cortical layer but significantly increased the blood supply to the median zone of this region of the kidneys. A pronounced natriuretic reaction produced by inhibition of this ion develops. An inhibitor of cyclooxygenase indomethacin (3 mg/kg orally, 5 days) completely eliminated an increase of the blood flow in the cortical median zone but failed to prevent an increase of diuresis and urinary excretion of sodium in response to the diuretic administration. An inhibitor of kallikrein contrykal (5000 U/kg subcutaneously) produced no effect on diuretic and natriuretic effects of the drug but prevented the hemodynamic shift in the renal cortex. A blocker of dopaminergic receptors haloperidol (3 mg/kg subcutaneously) caused no changes in the rat kidney response to ethacrynic acid. Prostaglandins and kinins formed in the kidneys under the influence of the diuretic are thought to be involved in the mechanism of dilatation of vessels of the cortical layer median zone but play no significant role in the formation of its natriuretic effect.
在对麻醉大鼠进行的实验中发现，依他尼酸（静脉注射3毫克/千克）对皮质层内部区域的血流没有影响，但显著增加了肾脏该区域中间区域的血液供应。抑制该离子会产生明显的利钠反应。环氧化酶抑制剂吲哚美辛（口服3毫克/千克，持续5天）完全消除了皮质中间区域血流的增加，但未能阻止给药后利尿和尿钠排泄的增加。激肽释放酶抑制剂抑肽酶（皮下注射5000单位/千克）对该药物的利尿和利钠作用没有影响，但阻止了肾皮质的血流动力学变化。多巴胺能受体阻滞剂氟哌啶醇（皮下注射3毫克/千克）对大鼠肾脏对依他尼酸的反应没有影响。利尿剂作用下在肾脏中形成的前列腺素和激肽被认为参与了皮质层中间区域血管扩张的机制，但在其利钠作用的形成中不起重要作用。
