Kuz'min O B, Tarasov S V
Farmakol Toksikol. 1990 Nov-Dec;53(6):24-6.
Strophanthin was shown to increase the blood flow in the external, internal zones of the cortex and the external medulla of the rat kidney without influencing the blood supply to the internal zone of the medulla. Contrikal eliminates the vasodilating effect of the drug in the mentioned zones of the renal tissue and significantly increases its natriuretic action. Indomethacin also prevents the hemodynamic shift occurring in the kidneys under the influence of strophanthin but fails to change the character of the natriuretic effect of the drug. Captopril exerts no influence on the increase of the blood flow in the external medulla but eliminates the vasodilating effect of strophanthin in the cortex and significantly potentiates its natriuretic action.
毒毛花苷被证明可增加大鼠肾脏皮质的外层、内层区域以及髓质外层的血流量，而不影响髓质内层的血液供应。康力龙可消除该药物在肾组织上述区域的血管舒张作用，并显著增强其利钠作用。吲哚美辛也可防止毒毛花苷作用下肾脏发生的血流动力学变化，但未能改变该药物的利钠作用特征。卡托普利对髓质外层血流量的增加无影响，但可消除毒毛花苷在皮质的血管舒张作用，并显著增强其利钠作用。
