Isolation of cDNAs coding for epitopes shared by microtubule-associated proteins and neurofibrillary tangle in Alzheimer's disease.
作者信息
Brion J P, Cheetham M E, Robinson P A, Couck A M, Anderton B H
机构信息
St. George's Hospital Medical School, Department of Immunology, London, England.
出版信息
FEBS Lett. 1987 Dec 21;226(1):28-32. doi: 10.1016/0014-5793(87)80544-6.
PMID:2446926
Abstract
5 cross-hybridizing cDNA clones of sizes 2.2 (3 cDNAs), 1.3 and 0.8 kb corresponding to tau microtubule-associated protein have been isolated from a rat brain lambda gt11 expression library. Antibodies affinity-purified using the fusion protein encoded by the cDNAs were observed to label tau polypeptides on Western blots and Alzheimer's neurofibrillary tangles.
摘要
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