Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), Campus Universitário Trindade, 88040-900, Florianópolis, SC, Brazil.
Macromol Biosci. 2014 May;14(5):709-19. doi: 10.1002/mabi.201300465. Epub 2014 Jan 28.
The development of novel xyloglucan-block-poly(ϵ-caprolactone) (XGO-b-PCL) nanoparticles coated with the mucoadhesive polysaccharide chitosan is described. XGO-b-PCL nanoparticles show monodisperse size distribution (Rh = 50 nm). Curcumin is successfully encapsulated within the PCL core within drug to polymer ratio of 1:5 (w/w). The coating of nanoparticles with chitosan results in an increased particle size and positive surface charge due to the polycation nature of the chitosan. Mucoadhesive properties of chitosan-coated nanoparticles are demonstrated by its exceptional ability to interact with mucin through electrostatic forces. Finally, in vitro studies show that curcumin-loaded nanoparticles exhibit higher cytotoxic effects against B16F10 melanoma cells than L929 fibroblast cells.
新型木葡聚糖-block-聚(ε-己内酯)(XGO-b-PCL)纳米粒子的开发，该纳米粒子用粘多糖壳聚糖进行了涂层修饰。XGO-b-PCL 纳米粒子显示出单分散的粒径分布（Rh=50nm）。姜黄素在药物与聚合物比例为 1:5（w/w）的情况下成功地被包裹在 PCL 核内。由于壳聚糖的聚阳离子性质，纳米粒子的涂层导致粒径增加和表面带正电荷。壳聚糖涂层纳米粒子的粘弹性通过其与粘蛋白的静电相互作用的特殊能力得到证明。最后，体外研究表明，负载姜黄素的纳米粒子对 B16F10 黑色素瘤细胞的细胞毒性作用高于 L929 成纤维细胞。
