Scheiber Ivo, Dringen Ralf, Mercer Julian F B
Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.
Met Ions Life Sci. 2013;13:359-87. doi: 10.1007/978-94-007-7500-8_11.
Copper is an essential trace metal that is required for the catalysis of several important cellular enzymes. However, since an excess of copper can also harm cells due to its potential to catalyze the generation of toxic reactive oxygen species, transport of copper and the cellular copper content are tightly regulated. This chapter summarizes the current knowledge on the importance of copper for cellular processes and on the mechanisms involved in cellular copper uptake, storage and export. In addition, we will give an overview on disturbances of copper homeostasis that are characterized by copper overload or copper deficiency or have been connected with neurodegenerative disorders.
铜是一种必需的痕量金属，是多种重要细胞酶催化反应所必需的。然而，由于过量的铜也可能因其催化产生有毒活性氧物种的潜力而损害细胞，因此铜的运输和细胞内铜含量受到严格调控。本章总结了目前关于铜对细胞过程的重要性以及细胞铜摄取、储存和输出所涉及机制的知识。此外，我们将概述以铜过载或铜缺乏为特征或与神经退行性疾病相关的铜稳态紊乱。
