克里特岛的猫抓病：最新情况
Cat-scratch disease in Crete: an update.
作者信息
Minadakis Georgios, Angelakis Emmanouil, Chochlakis Dimosthenis, Tselentis Yannis, Psaroulaki Anna
机构信息
Laboratory of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, WHO Collaborating Center for Mediterranean Zoonoses, University of Crete, Staurakia-Voutes, Crete, Greece.
出版信息
Infect Dis Rep. 2011 Dec 5;3(2):e15. doi: 10.4081/idr.2011.e15. eCollection 2011 Sep 7.
There are few epidemiological and clinical studies about the presence of cat scratch disease (CSD) on the island of Crete. The objective of this study was to analyze a large number of patients with suspected CSD to define the frequency of Bartonella infections in Crete. From January 2005 to October 2008, we studied patients with suspected CSD from hospitals in Crete. Sera of the referred patients were tested by immunofluorescence assay (IFA). For some patients, we also received lymph nodes and blood samples that we tested for the presence of Bartonella henselae by molecular assays. Overall, we tested 507 serum samples and we found 56 (11%) cases of CSD. PCR assay was positive for 2 patients; one had a B. henselae positive lymph node and the other a positive whole blood sample. Significantly more CSD cases (62.5%, 35 of 56) were reported in children than in infants and adults (P<0.05). Moreover, we identified that most cases of CSD occurred between May and September (P=0.002) and December and January. CSD is prevalent in Crete and is mostly associated with an increase in outdoor activity.
关于克里特岛猫抓病（CSD）的存在，流行病学和临床研究较少。本研究的目的是分析大量疑似CSD患者，以确定克里特岛巴尔通体感染的频率。2005年1月至2008年10月，我们对克里特岛各医院的疑似CSD患者进行了研究。转诊患者的血清通过免疫荧光测定（IFA）进行检测。对于部分患者，我们还获取了淋巴结和血液样本，通过分子检测方法检测是否存在汉赛巴尔通体。总体而言，我们检测了507份血清样本，发现56例（11%）CSD病例。聚合酶链反应（PCR）检测有2名患者呈阳性；一名患者的淋巴结汉赛巴尔通体检测呈阳性，另一名患者的全血样本检测呈阳性。报告显示，儿童CSD病例（62.5%，56例中的35例）显著多于婴儿和成人（P<0.05）。此外，我们还发现大多数CSD病例发生在5月至9月（P=0.002）以及12月和1月。CSD在克里特岛很普遍，且大多与户外活动增加有关。
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