Busch-Dienstfertig Melanie, González-Rodríguez Sara
Department of Anesthesiology and Critical Care Medicine; Charité Campus Benjamin Franklin; Freie Universität Berlin; Berlin, Germany.
JAKSTAT. 2013 Oct 1;2(4):e27638. doi: 10.4161/jkst.27638. Epub 2014 Jan 2.
During inflammation, several mediators directly or indirectly induce pain including pro-inflammatory cytokines and there is evidence that the JAK-STAT pathway is involved in the formation of pronociceptive cytokines. The same pathway, however, is also of importance for anti-inflammatory cytokines such as IL-4 to counteract the inflammatory reaction and-as it seems based on the current literature-nociceptive symptoms. Current therapeutic approaches targeting molecules of the JAK-STAT signaling cascade are auspicious but as this review demonstrates, more experimental and clinical studies are required to decipher the specific contribution of this pathway in the modulation of pain.
在炎症过程中，包括促炎细胞因子在内的多种介质直接或间接诱发疼痛，并且有证据表明JAK-STAT通路参与伤害感受性细胞因子的形成。然而，同一通路对于抗炎细胞因子（如IL-4）对抗炎症反应以及——根据目前的文献——伤害感受性症状似乎也很重要。目前针对JAK-STAT信号级联分子的治疗方法前景良好，但正如本综述所示，需要更多的实验和临床研究来解读该通路在疼痛调节中的具体作用。
