Kraev Krasimir, Geneva-Popova Mariela, Hristov Bozhidar, Uchikov Petar, Popova Stanislava, Kraeva Maria, Basheva-Kraeva Yordanka, Sheytanov Ivan, Petranova Tzvetanka, Stoyanova Nina, Atanassov Marin
Department of Propaedeutics of Internal Diseases "Prof. Dr. Anton Mitov", Faculty of Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Clinic of Rheumatology, University Hospital "St. George", 4000 Plovdiv, Bulgaria.
Life (Basel). 2023 Sep 29;13(10):1994. doi: 10.3390/life13101994.
This review explores the link between immune interactions and chronic pain, offering new perspectives on treatment. It focuses on Janus kinase (JAK) inhibitors' potential in pain management. Immune cells' communication with neurons shapes neuroinflammatory responses, and JAK inhibitors' effects on pain pathways are discussed, including cytokine suppression and microglial modulation. This review integrates studies from rheumatoid arthritis (RA) pain and central sensitization to highlight connections between immune interactions and pain. Studies on RA joint pain reveal the shift from cytokines to sensitization. Neurobiological investigations into central sensitization uncover shared pathways in chronic pain. Clinical evidence supports JAK inhibitors' efficacy on pain-related outcomes and their effects on neurons and immune cells. Challenges and future directions are outlined, including interdisciplinary collaboration and dosing optimization. Overall, this review highlights JAK inhibitors' potential to target immune-mediated pain pathways, underscoring the need for more research on immune-pain connections.
本综述探讨了免疫相互作用与慢性疼痛之间的联系，为治疗提供了新的视角。它聚焦于 Janus 激酶（JAK）抑制剂在疼痛管理中的潜力。免疫细胞与神经元的通讯塑造了神经炎症反应，并讨论了 JAK 抑制剂对疼痛通路的影响，包括细胞因子抑制和小胶质细胞调节。本综述整合了类风湿性关节炎（RA）疼痛和中枢敏化的研究，以突出免疫相互作用与疼痛之间的联系。对 RA 关节疼痛的研究揭示了从细胞因子到敏化的转变。对中枢敏化的神经生物学研究发现了慢性疼痛中的共同通路。临床证据支持 JAK 抑制剂对疼痛相关结局的疗效及其对神经元和免疫细胞的影响。概述了挑战和未来方向，包括跨学科合作和给药优化。总体而言，本综述强调了 JAK 抑制剂靶向免疫介导的疼痛通路的潜力，强调了对免疫-疼痛联系进行更多研究的必要性。
