Gospodaryov Dmytro V, Yurkevych Ihor S, Jafari Mahtab, Lushchak Volodymyr I, Lushchak Oleh V
Department of Biochemistry and Biotechnology, Vassyl Stefanyk Precarpathian National University, Ivano-Frankivsk 76025, Ukraine.
Longev Healthspan. 2013 Apr 2;2(1):5. doi: 10.1186/2046-2395-2-5.
This study was conducted to evaluate the effects of rhizome powder from the herb Rhodiola rosea, a traditional Western Ukraine medicinal adaptogen, on lifespan and age-related physiological functions of the fruit fly Drosophila melanogaster.
Flies fed food supplemented with 5.0 mg/ml and 10.0 mg/ml of R. rosea rhizome powder had a 14% to 17% higher median lifespan, whereas at 30.0 mg/ml lifespan was decreased by 9% to 12%. The preparation did not decrease fly fecundity.The effect of R. rosea supplement on lifespan was dependent on diet composition. Lifespan extension by 15% to 21% was observed only for diets with protein-to-carbohydrate ratios less than 1. Lifespan extension was also dependent on total concentration of macronutrients. Thus, for the diet with 15% yeast and 15% sucrose there was no lifespan extension, while for the diet with protein-to-carbohydrate ratio 20:1 R. rosea decreased lifespan by about 10%.Flies fed Rhodiola preparation were physically more active, less sensitive to the redox-cycling compound menadione and had a longer time of heat coma onset compared with controls. Positive effects of Rhodiola rhizome on stress resistance and locomotor activity were highest at the 'middle age'.
The present data show that long-term food supplementation with R. rosea rhizome not only increases D. melanogaster lifespan, but also delays age-related decline of physical activity and increases stress resistance, what depends on protein-to-carbohydrate ratio of the diet.
本研究旨在评估源自乌克兰西部传统药用适应原植物红景天根茎粉对果蝇寿命及与年龄相关生理功能的影响。
喂食添加5.0毫克/毫升和10.0毫克/毫升红景天根茎粉食物的果蝇，其平均寿命提高了14%至17%，而在30.0毫克/毫升时，寿命缩短了9%至12%。该制剂并未降低果蝇的繁殖力。红景天补充剂对寿命的影响取决于饮食组成。仅在蛋白质与碳水化合物比例小于1的饮食中观察到寿命延长了15%至21%。寿命延长还取决于常量营养素的总浓度。因此，对于含有15%酵母和15%蔗糖的饮食，未观察到寿命延长，而对于蛋白质与碳水化合物比例为20:1的饮食，红景天使寿命缩短了约10%。与对照组相比，喂食红景天制剂的果蝇身体更活跃，对氧化还原循环化合物甲萘醌的敏感性更低，热昏迷发作时间更长。红景天根茎对压力抗性和运动活性的积极影响在“中年”时最为显著。
目前的数据表明，长期用红景天根茎补充食物不仅能延长果蝇寿命，还能延缓与年龄相关的身体活动能力下降并增强压力抗性，这取决于饮食中的蛋白质与碳水化合物比例。
