Jafari Mahtab, Felgner Jeffrey S, Bussel Irvin I, Hutchili Tony, Khodayari Behnood, Rose Michael R, Vince-Cruz C, Mueller Laurence D
Department of Pharmaceutical Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Rejuvenation Res. 2007 Dec;10(4):587-602. doi: 10.1089/rej.2007.0560.
Using the fruit fly, Drosophila melanogaster, we investigated the effects of Rhodiola on life-span. Rhodiola is a plant root used in traditional Chinese medicine that may increase an organism's resistance to stress. It has been proposed that Rhodiola can extend longevity and improve health span by alleviating oxidative stress. Rhodiola supplied every other day at 30 mg/mL significantly increased the lifespan of Drosophila melanogaster. When comparing the distribution of deaths between Rhodiola-supplemented and control flies, Rhodiola-fed flies exhibited decelerated aging. Although the observed extension in lifespan was associated with statistically insignificant reductions in fecundity, correcting for a possible dietary restriction effect still did not eliminate the difference between supplemented and control flies, nor does the effect of Rhodiola depend on dietary manipulation, strongly suggesting that Rhodiola is not a mere dietary restriction mimetic. Although this study does not reveal the causal mechanism behind the effect of Rhodiola, it does suggest that the supplement is worthy of continued investigation, unlike the other Chinese herbals, Lu Duo Wei (LDW), Bu Zhong Yi Qi Tang (BZYQT), San Zhi Pian (SZP, Three Imperial Mushrooms), Hong Jing Tian (Rhodiola) that were evaluated in this study.
我们利用果蝇（黑腹果蝇）研究了红景天对寿命的影响。红景天是一种用于传统中药的植物根茎，可能会增强生物体对压力的抵抗力。有人提出，红景天可以通过减轻氧化应激来延长寿命并改善健康寿命。每隔一天以30毫克/毫升的剂量提供红景天，可显著延长黑腹果蝇的寿命。在比较补充红景天的果蝇和对照果蝇的死亡分布时，喂食红景天的果蝇衰老速度减缓。尽管观察到的寿命延长与繁殖力在统计学上无显著降低有关，但校正可能的饮食限制效应仍未消除补充组和对照组果蝇之间的差异，而且红景天的作用也不依赖于饮食控制，这强烈表明红景天不仅仅是一种饮食限制模拟物。尽管这项研究没有揭示红景天作用背后的因果机制，但它确实表明这种补充剂值得继续研究，与本研究中评估的其他中药如绿萝维（LDW）、补中益气汤（BZYQT）、三芝片（SZP，三帝菇）、红景天不同。
