Baracho Nilo César do Vale, Ribeiro Rafaela Vazi, Pereira Renato Maduro, Irulegui Roseane de Souza Cândido
FMIt, Medical School of Itajuba, ItajubaMG, Brazil.
FMIt, ItajubaMG, Brazil.
Acta Cir Bras. 2014 Jan;29(1):24-9. doi: 10.1590/S0102-86502014000100004.
To evaluate the effects of acute administration of Sedum dendroideum on the gastric histopathology of rats after the administration of indomethacin.
Twenty four Wistar rats were randomized into three groups, submitted to feeding privation for 24 hours prior to the oral administration of 50 mg/Kg of indomethacin and during the experimental period of six hours. The control group (C) was giving distilled water, the extract group (E) was treated with the extract of Sedum dendroideum and the group Omeoprazole (O) received 20 mg/Kg of omeoprazole. All the treatments were carried out thirty minutes prior to the administration of indomethacin. After six hour, the stomach of the animals was extirpated for histopathological analysis, which took into account the presence of erosive gastritis, hyperemia and sub mucosa edema.
In group C, eight out of eight animals presented that type of lesion, in group E, this number was the same and in group O, three out of the eight rats presented erosive gastritis.
Sedum dendroideum extract did not produce reduction in the erosive gastritis process. As expected, the treatment with omeoprazole produced a major reduction, when compared with the control group.
评估急性给予树花景天对吲哚美辛给药后大鼠胃组织病理学的影响。
将24只Wistar大鼠随机分为三组，在口服50mg/Kg吲哚美辛之前以及6小时的实验期间禁食24小时。对照组（C）给予蒸馏水，提取物组（E）用树花景天提取物治疗，奥美拉唑组（O）接受20mg/Kg奥美拉唑。所有处理均在给予吲哚美辛前30分钟进行。6小时后，取出动物的胃进行组织病理学分析，考虑糜烂性胃炎、充血和黏膜下水肿的存在情况。
C组8只动物中有8只出现该类型病变，E组该数字相同，O组8只大鼠中有3只出现糜烂性胃炎。
树花景天提取物未使糜烂性胃炎进程减轻。与对照组相比，正如预期的那样，奥美拉唑治疗产生了更大程度的减轻。
