Carrasco Viviane, Pinto Lorraine Aparecida, Cordeiro Kátia Wolff, Cardoso Claudia Andrea Lima, Freitas Karine de Cássia
Federal University of Grande Dourados, School of Health Sciences, Dourados (Universidade Federal da Grande Dourados, Faculdade de Ciências da Saúde), Mato Grosso do Sul, Brazil.
Federal University of Mato Grosso do Sul, Medical School, (Universidade Federal de Mato Grosso do Sul, Faculdade de Medicina), Campo Grande, Mato Grosso do Sul, Brazil.
J Ethnopharmacol. 2014 Dec 2;158 Pt A:345-51. doi: 10.1016/j.jep.2014.10.042. Epub 2014 Oct 30.
The leaves of Sedum dendroideum, commonly known as balsam, have long been employed for the treatment of gastric ulcers. The aim of study was to evaluate the antiulcer activity and toxicological properties of Sedum dendroideum using induced gastric ulcer models in Wistar rats.
The hydroethanolic extract of Sedum dendroideum (ESD) was analyzed using an acute ulcer model using ethanol and indomethacin and a chronic ulcer model using acetic acid. The toxicity was evaluated with acute and subacute toxicity tests. The gastric secretion was assessed by the performance of pyloric ligation and the gastric volume, pH, and hydrogen ion concentration. The mechanism of the gastroprotective activity of ESD through the involvement of nitric oxide and sulfhydryl compounds was assessed. Moreover, a phytochemical screening and antioxidant assays were performed.
No signs of toxicity were observed. In the ethanol-induced ulceration model, ESD doses of 25, 50, and 100mg/kg significantly reduced the gastric lesions by 66.03%, 71.11%, and 70.82%, respectively. In the indomethacin-induced ulceration model, ESD doses of 25, 50, and 100mg/kg significantly reduced the gastric lesions by 89.88%, 94.36%, and 90.64%, respectively. Treatment with ESD at 50mg/kg and cimetidine at 200mg/kg significantly reduced acetic acid-induced ulcerations and resulted in 92.99% and 77.16% cure, respectively. ESD doses of 25, 50, and 100mg/kg inhibited oxidation by 79.7%, 82.4%, and 82.3%, respectively. The antiulcer activity of ESD may involve sulfhydryl compounds, considering that this activity was inhibited in the animals treated with sulfhydryl compound blockers. Furthermore, ESD increased mucus secretion and reduced gastric acidity and volume.
The leaf extract of Sedum dendroideum exhibited gastroprotective activity, potentially due to sulfhydryl compounds and antioxidant activity. Therefore, other studies are warranted to elucidate the antiulcer properties of these compounds.
垂盆草的叶子，通常被称为香脂草，长期以来一直用于治疗胃溃疡。本研究的目的是使用Wistar大鼠的诱导胃溃疡模型评估垂盆草的抗溃疡活性和毒理学特性。
使用乙醇和吲哚美辛的急性溃疡模型以及乙酸的慢性溃疡模型分析垂盆草的水乙醇提取物（ESD）。通过急性和亚急性毒性试验评估毒性。通过幽门结扎实验评估胃分泌情况以及胃体积、pH值和氢离子浓度。评估ESD通过一氧化氮和巯基化合物参与的胃保护活性机制。此外，进行了植物化学筛选和抗氧化测定。
未观察到毒性迹象。在乙醇诱导的溃疡模型中，25、50和100mg/kg剂量的ESD分别使胃损伤显著减少66.03%、71.11%和70.82%。在吲哚美辛诱导的溃疡模型中，25、50和100mg/kg剂量的ESD分别使胃损伤显著减少89.88%、94.36%和90.64%。50mg/kg的ESD和200mg/kg的西咪替丁治疗显著减少了乙酸诱导的溃疡，治愈率分别为92.99%和77.16%。25、50和100mg/kg剂量的ESD分别抑制氧化79.7%、82.4%和82.3%。考虑到在用巯基化合物阻滞剂治疗的动物中该活性受到抑制，ESD的抗溃疡活性可能涉及巯基化合物。此外，ESD增加了黏液分泌，降低了胃酸度和胃体积。
垂盆草叶提取物表现出胃保护活性，可能归因于巯基化合物和抗氧化活性。因此，有必要进行其他研究以阐明这些化合物的抗溃疡特性。
