Guo Qing, Dai Sheng-Bin, Shen Feng, Yu Di, Shen Shu-Tong, Zhang Qu, Huang Jun-Xing, Wu Zheng-Dong
Department of Radiotherapy, Taizhou People's Hospital, South Hailing Road 395, Taizhou, 225300, China.
Tumour Biol. 2014 May;35(5):4977-82. doi: 10.1007/s13277-014-1655-0. Epub 2014 Jan 29.
Vascular endothelial growth factor (VEGF) polymorphisms, specifically +405G/C (rs2010963), reportedly influence the risk for various digestive cancers. However, the consequences of these polymorphisms remain controversial and ambiguous. Therefore, we performed a meta-analysis of 11 studies with VEGF +405G/C genotyping on 2,862 patients and 3,028 controls using the random effects model. We obtained a pooled odds ratio (OR) of 1.04 (95% confidence interval (CI) = 0.86-1.26) for the recessive genetic model, 1.07 (95% CI = 0.81-1.42) for the dominant genetic model, 1.09 (95% CI = 0.81-1.47) for the homozygote comparison, and 1.03 (95% CI = 0.83-1.27) for the heterozygote comparison. In the subgroup analysis of the recessive model, the OR was 1.20 (95% CI = 1.02-1.40) in colorectal cancer. These results show that VEGF +405G/C polymorphisms are unlikely to be a major determinant of susceptibility to digestive cancer. Furthermore, the subgroup analysis of recessive model indicates that VEGF +405G/C polymorphisms increase the risk for colorectal cancer.
据报道，血管内皮生长因子（VEGF）基因多态性，特别是+405G/C（rs2010963），会影响各种消化系统癌症的发病风险。然而，这些基因多态性的影响仍存在争议且不明确。因此，我们采用随机效应模型，对11项研究进行了荟萃分析，这些研究对2862例患者和3028例对照进行了VEGF +405G/C基因分型。隐性遗传模型的合并比值比（OR）为1.04（95%置信区间（CI）=0.86-1.26），显性遗传模型为1.07（95%CI=0.81-1.42），纯合子比较为1.09（95%CI=0.81-1.47），杂合子比较为1.03（95%CI=0.83-1.27）。在隐性模型的亚组分析中，结直肠癌的OR为1.20（95%CI=1.02-1.40）。这些结果表明，VEGF +405G/C基因多态性不太可能是消化系统癌症易感性的主要决定因素。此外，隐性模型的亚组分析表明，VEGF +405G/C基因多态性会增加患结直肠癌的风险。
