Guan Xiaoxiang, Zhao Hui, Niu Jiangong, Tang Dongfeng, Ajani Jaffer A, Wei Qingyi
Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
BMC Gastroenterol. 2009 Oct 16;9:77. doi: 10.1186/1471-230X-9-77.
Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population.
The risk associated with genotypes and haplotypes of four TGFB1 SNPs and four VEGF SNPs were determined by multivariate logistic regression analysis in 171 patients with gastric cancer and 353 cancer-free controls frequency-matched by age, sex and ethnicity.
Compared with the VEGF-634GG genotype, the -634CG genotype and the combined -634CG+CC genotypes were associated with a significantly elevated risk of gastric cancer (adjusted OR = 1.88, 95% CI = 1.24-2.86 and adjusted OR = 1.56, 95% CI = 1.07-2.27, respectively). However, none of other TGFB1 and VEGF SNPs was associated with risk of gastric cancer.
Our data suggested that the VEGF-634G>C SNP may be a marker for susceptibility to gastric cancer, and this finding needs to be validated in larger studies.
转化生长因子β1（TGF-β1）和血管内皮生长因子（VEGF）在胃癌发生的多步骤过程中均起关键作用。TGFB1和VEGF基因的单核苷酸多态性（SNP）与许多癌症的风险及进展相关。在本研究中，我们调查了这两个基因潜在的功能性SNP与美国人群胃癌风险之间的关联。
通过多因素逻辑回归分析，在171例胃癌患者和353例按年龄、性别和种族进行频率匹配的无癌对照中，确定4个TGFB1 SNP和4个VEGF SNP的基因型及单倍型相关风险。
与VEGF -634GG基因型相比，-634CG基因型及-634CG + CC组合基因型与胃癌风险显著升高相关（校正比值比分别为1.88，95%可信区间为1.24 - 2.86；校正比值比为1.56，95%可信区间为1.07 - 2.27）。然而，其他TGFB1和VEGF SNP均与胃癌风险无关。
我们的数据表明，VEGF -634G>C SNP可能是胃癌易感性的一个标志物，这一发现需要在更大规模的研究中得到验证。
