Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan, Korea.
Invest Ophthalmol Vis Sci. 2014 Mar 4;55(3):1241-51. doi: 10.1167/iovs.13-12536.
To investigate the characteristics of the lamina cribrosa (LC) depth in healthy eyes using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT).
Serial horizontal B-scans of the optic nerve head were obtained using EDI SD-OCT for both eyes of 150 healthy subjects. Anterior LC surface (ALCS) depths were measured with B-scan images from equidistant planes in each eye and defined as the distance from the Bruch's membrane opening plane to the anterior LC surface. The ALCS depths were compared between eyes within each subject. A linear mixed model was used to identify factors associated with the ALCS depth.
The average ALCS depth was 402.06 ± 101.46 μm (range, 193.08-826.81). The ALCS depth was not significantly different between the right and left eyes (Ps > 0.05 at all planes). There was a strong intereye correlation within subjects (Rs ≥ 0.808 at all planes, Ps < 0.0001 at all planes). The ALCS depth was largest in the superior periphery and smallest in the central inferior plane. ALCS depth was larger in males (P < 0.05) and also larger in eyes with shorter axial length (P = 0.029).
This study reports the range of ALCS depth in healthy subjects. These data suggest that ALCS depth is related to sex and axial length.
使用增强深度成像（EDI）谱域光学相干断层扫描（SD-OCT）研究健康眼中的筛板（LC）深度特征。
对 150 名健康受试者的双眼进行 EDI SD-OCT 视神经头水平序列 B 扫描。从前 LC 表面（ALCS）深度用每只眼等距平面的 B 扫描图像进行测量，并定义为从 Bruch 膜开口平面到前 LC 表面的距离。比较了每只眼内各眼的 ALCS 深度。线性混合模型用于确定与 ALCS 深度相关的因素。
平均 ALCS 深度为 402.06 ± 101.46 μm（范围，193.08-826.81）。右眼和左眼之间的 ALCS 深度无显著差异（所有平面 Ps > 0.05）。受试者内两眼之间具有很强的相关性（所有平面 Rs ≥ 0.808，所有平面 Ps < 0.0001）。ALCS 深度在上方周边最大，在中央下方平面最小。男性的 ALCS 深度较大（P < 0.05），眼轴较短的 ALCS 深度也较大（P = 0.029）。
本研究报告了健康受试者的 ALCS 深度范围。这些数据表明，ALCS 深度与性别和眼轴长度有关。
