Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China.
Invest Ophthalmol Vis Sci. 2014 Mar 4;55(3):1292-8. doi: 10.1167/iovs.13-13351.
The venous choroidal blood drains through the superior orbital vein into the intracranial cavernous sinus. The cerebrospinal fluid pressure (CSFP) may thus influence the choroidal venous blood pressure. Since volume and thickness of the choroid depend on its pressure, we tested the hypothesis whether the subfoveal choroidal thickness (SFCT) is associated with CSFP.
The population-based Beijing Eye Study 2011 included 3468 individuals. A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging for measurement of SFCT. The CSFP was calculated as CSFP (mm Hg) = 0.44 × Body Mass Index (kg/m(2)) + 0.16 × Diastolic Blood Pressure (mm Hg) - 0.18 × Age (years) - 1.91.
Mean calculated CSFP was 8.8 ± 3.7 mm Hg and mean SFCT was 254 ± 107 μm. In multivariate analysis, SFCT was significantly associated with higher CSFP (P = 0.009; standardized coefficient β: 0.08; regression coefficient B: 2.27) after adjusting for lower age (P < 0.001; β: -0.36; B: -3.99), shorter axial length (P < 0.001; β: -0.37; B: -35.7), lower body mass index (P = 0.02; β: -0.05; B: -1.51), and higher corneal curvature radius (P < 0.001; β: 0.10; B: 41.1). In univariate analysis, SFCT increased by 9.2 μm (95% confidence interval: 8.3, 10.1) for each mm Hg increase in CSFP. In a reverse manner, CSFP was significantly associated with thicker SFCT (P < 0.001; B: 0.007; β: 0.21), after adjusting for region of habitation (P < 0.001; B: -0.31; β: -2.32), higher levels of glucose (P = 0.02; B: 0.10; β: 0.04) and triglycerides (P < 0.001; B: 0.13; β: 0.09), higher intraocular pressure (P < 0.001; B: 0.17; β: 0.12), and thinner lens (P < 0.001; B: -2.39; β: -0.22).
Thicker subfoveal choroid was associated with higher CSFP after adjustment for age, axial length, body mass index, and corneal curvature radius. This association may explain thicker SFCT measurements in the morning than evening. It shows the importance of the CSFP for the physiology of the eye.
脉络膜静脉通过眼上静脉流入颅内海绵窦。因此，脑脊液压力（CSFP）可能会影响脉络膜静脉血压。由于脉络膜的体积和厚度取决于其压力，我们检验了假设：即黄斑下脉络膜厚度（SFCT）是否与 CSFP 相关。
基于人群的北京眼研究 2011 年纳入了 3468 名个体。进行了详细的眼科检查，包括使用增强深度成像的光谱域光学相干断层扫描（SD-OCT）来测量 SFCT。CSFP 的计算公式为 CSFP（mmHg）= 0.44 × 体重指数（kg/m²）+ 0.16 × 舒张压（mmHg）- 0.18 × 年龄（岁）- 1.91。
平均计算出的 CSFP 为 8.8 ± 3.7mmHg，平均 SFCT 为 254 ± 107μm。在多变量分析中，在调整了较低的年龄（P < 0.001；β：-0.36；B：-3.99）、较短的眼轴长度（P < 0.001；β：-0.37；B：-35.7）、较低的体重指数（P = 0.02；β：-0.05；B：-1.51）和较高的角膜曲率半径（P < 0.001；β：0.10；B：41.1）后，SFCT 与较高的 CSFP 显著相关（P = 0.009；标准化系数β：0.08；回归系数 B：2.27）。在单变量分析中，CSFP 每增加 1mmHg，SFCT 增加 9.2μm（95%置信区间：8.3，10.1）。相反，CSFP 与更厚的 SFCT 显著相关（P < 0.001；B：0.007；β：0.21），在调整了居住地区（P < 0.001；B：-0.31；β：-2.32）、较高的血糖（P = 0.02；B：0.10；β：0.04）和甘油三酯（P < 0.001；B：0.13；β：0.09）、较高的眼内压（P < 0.001；B：0.17；β：0.12）和更薄的晶状体（P < 0.001；B：-2.39；β：-0.22）后。
在调整年龄、眼轴长度、体重指数和角膜曲率半径后，黄斑下脉络膜更厚与 CSFP 升高相关。这种关联可能解释了为什么 SFCT 早晨的测量值比晚上厚。这表明 CSFP 对眼睛的生理学很重要。
