Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Invest Ophthalmol Vis Sci. 2015 Jan 20;56(2):810-5. doi: 10.1167/iovs.14-15736.
This study examined subfoveal choroidal thickness (SFCT) in eyes with cataracts.
The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years (range, 50-93 years of age). Enhanced depth imaging spectral domain optical coherence tomography was applied for measurement of SFCT. Using lens photographs, we graded cataracts by the Age-Related Eye Disease Study system.
Assessments of SFCT and cataract were available for 2548 subjects. After adjusting for age, axial length, sex, anterior chamber depth, and lens thickness, we found that SFCT was not significantly associated with presence of nuclear cataract (P = 0.41). Conversely, the degree of nuclear cataract (P = 0.73) was not significantly associated with SFCT after adjusting for age and sex. In contrast, thicker SFCT was significantly associated with lower degree of posterior subcapsular cataract (P = 0.027; standardized regression coefficient β: -0.04; regression coefficient B: -127; 95% confidence interval [CI]: -240 to -15) or with lower degree of cortical cataract (P = 0.028; β:-0.06; B: -51.5; 95% CI: -97.3 to -5.59) after adjusting for younger age, shorter axial length, and deeper anterior chamber. Conversely, the degree of posterior subcapsular cataract (P = 0.027; β:-0.06) or the degree of cortical cataract (P = 0.01; β: -2.55) was associated with thinner SFCT in multivariate analysis. Correspondingly in binary regression analysis, presence of subcapsular cataract was associated with older age (P < 0.001; odds ratio (OR): 1.11; 95% CI: 1.09-1.14) and thinner SFCT (P = 0.006; OR: 0.997; 95% CI: 0.995-0.999).
Although nuclear cataract was not significantly associated with an abnormal SFCT, the association between thin SFCT and subcapsular cataract or cortical cataract may have clinical importance, because thin SFCT is associated with low vision.
本研究旨在探讨白内障患者的黄斑中心凹下脉络膜厚度（SFCT）。
基于人群的北京眼研究 2011 年纳入了 3468 名平均年龄为 64.6±9.8 岁（50-93 岁）的个体。采用增强深度成像谱域光学相干断层扫描测量 SFCT。通过晶状体照片，我们按照年龄相关性眼病研究系统对白内障进行分级。
对 2548 名受试者的 SFCT 和白内障评估结果可用。在调整年龄、眼轴长度、性别、前房深度和晶状体厚度后，我们发现 SFCT 与核性白内障的存在无显著相关性（P=0.41）。相反，在调整年龄和性别后，核性白内障的程度（P=0.73）与 SFCT 无显著相关性。相比之下，SFCT 较厚与后囊下白内障的程度较低（P=0.027；标准化回归系数β：-0.04；回归系数 B：-127；95%置信区间[CI]：-240 至-15）或皮质性白内障的程度较低（P=0.028；β：-0.06；B：-51.5；95%CI：-97.3 至-5.59）显著相关，在调整年龄较小、眼轴较短和前房较深后。相反，在后囊下白内障的程度（P=0.027；β：-0.06）或皮质性白内障的程度（P=0.01；β：-2.55）与多元分析中 SFCT 较薄相关。相应地，在二元回归分析中，后囊下白内障的存在与年龄较大（P<0.001；优势比（OR）：1.11；95%CI：1.09-1.14）和 SFCT 较薄（P=0.006；OR：0.997；95%CI：0.995-0.999）相关。
尽管核性白内障与异常 SFCT 无显著相关性，但 SFCT 变薄与后囊下白内障或皮质性白内障之间的关联可能具有临床重要性，因为 SFCT 变薄与低视力相关。
