特发性颅内低血压患者的视网膜神经纤维层特征：一项回顾性病例系列研究。
Retinal nerve fiber layer characteristics in patients with spontaneous intracranial hypotension: a retrospective case series.
机构信息
Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Pain Management, Center for Intracranial Hypotension Management, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
出版信息
J Int Med Res. 2021 Oct;49(10):3000605211050791. doi: 10.1177/03000605211050791.
OBJECTIVE
To evaluate changes in retinal nerve fiber layer (RNFL) and macular thicknesses, included ganglion cell-inner plexiform layer (GCIPL) thickness, in patients with spontaneous intracranial hypotension (SIH).
METHODS
This was a retrospective, nonrandom, observational case series study. Comprehensive ophthalmic examinations and systemic examinations were performed. Spectral domain optical coherence tomography angiography scanning was used to measure peripapillary RNFL thickness and macular volume.
RESULTS
In total, 108 eyes in 54 patients with SIH were evaluated; these were compared with 108 eyes in 54 healthy controls. The mean ages were 38.2 ± 9.4 years (patients with SIH) and 38.9 ± 9.4 years (healthy controls). In both groups, 33 patients were women (61.1%). The peripapillary RNFL and GCIPL were thinner in patients with SIH than in healthy controls (100.08 ± 9.94 µm 104.83 ± 8.35 µm and 81.46 ± 5.67 µm 85.67 ± 4.57 µm, respectively). Among patients with SIH, the GCIPL was thinner in patients with visual field defects (79.81 ± 5.62 µm 82.39 ± 5.12 µm).
CONCLUSIONS
The RNFL and GCIPL were thinner in patients with SIH than in healthy controls. The GCIPL was thinner in eyes with visual field defects among patients with SIH.
目的
评估自发性颅内低血压（SIH）患者的视网膜神经纤维层（RNFL）和黄斑厚度变化，包括神经节细胞-内丛状层（GCIPL）厚度。
方法
这是一项回顾性、非随机、观察性病例系列研究。进行了全面的眼科检查和系统检查。使用谱域光相干断层扫描血管造影扫描测量视盘周围 RNFL 厚度和黄斑体积。
结果
共评估了 54 例 SIH 患者的 108 只眼，并与 54 名健康对照者的 108 只眼进行了比较。患者组的平均年龄为 38.2±9.4 岁，健康对照组为 38.9±9.4 岁。两组中，女性均为 33 例（61.1%）。与健康对照组相比，SIH 患者的视盘周围 RNFL 和 GCIPL 更薄（分别为 100.08±9.94µm 和 104.83±8.35µm；81.46±5.67µm 和 85.67±4.57µm）。在 SIH 患者中，视野缺损患者的 GCIPL 更薄（79.81±5.62µm 和 82.39±5.12µm）。
结论
与健康对照组相比，SIH 患者的 RNFL 和 GCIPL 更薄。在 SIH 患者中，视野缺损眼的 GCIPL 更薄。
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