Abbouda Alessandro, Estrada Alfredo Vega, Rodriguez Alejandra E, Alió Jorge L
2 Division of Ophthalmology, University of Rome "Sapienza", Rome - Italy.
Eur J Ophthalmol. 2014 May-Jun;24(3):320-4. doi: 10.5301/ejo.5000424. Epub 2014 Jan 22.
Anterior segment optical coherence tomography (OCT) is a relevant diagnostic tool in the evaluation of corneal changes following corneal crosslinking (CXL) treatment in patients infected by a severe fungal corneal infection.
Two patients with severe fungal keratitis that was unresponsive to medical treatment were treated with CXL. Corneal melting was present in all cases. Anterior segment OCT showed the preoperative depth and extension of the infiltrate and the modification during the follow-up.
Blockage of the melting was achieved in one patient and one patient developed a corneal perforation. Anterior segment OCT allowed control of the evolution of fungal infection and evaluation of the corneal tissue response to the CXL. It is also able to identify the extent and depth of the inflammation. This parameter seems more important than corneal pachymetry to ensure the safety of CXL procedures in infectious keratitis.
The different behavior of inflamed tissue with respect to UVA irradiance could be the main point to understand the different postoperative outcome.
眼前节光学相干断层扫描（OCT）是评估严重真菌性角膜感染患者角膜交联（CXL）治疗后角膜变化的一种重要诊断工具。
两名药物治疗无效的严重真菌性角膜炎患者接受了CXL治疗。所有病例均存在角膜溶解。眼前节OCT显示了术前浸润的深度和范围以及随访期间的变化。
一名患者实现了溶解的阻断，一名患者发生了角膜穿孔。眼前节OCT能够控制真菌感染的进展并评估角膜组织对CXL的反应。它还能够识别炎症的范围和深度。在确保感染性角膜炎CXL手术的安全性方面，该参数似乎比角膜测厚更重要。
炎症组织对紫外线A辐照的不同反应可能是理解不同术后结果的关键要点。
