Tanisawa Kumpei, Ito Tomoko, Sun Xiaomin, Cao Zhen-Bo, Sakamoto Shizuo, Tanaka Masashi, Higuchi Mitsuru
Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan;
Physiol Genomics. 2014 Mar 15;46(6):207-15. doi: 10.1152/physiolgenomics.00182.2013. Epub 2014 Jan 28.
High cardiorespiratory fitness (CRF) is associated with a reduced risk for dyslipidemia; however, blood lipid levels are also affected by individual genetic variations. We performed a cross-sectional study to determine whether CRF modifies polygenic risk for dyslipidemia. Serum levels of triglycerides (TG), LDL cholesterol (LDL-C), and HDL cholesterol (HDL-C) were measured in 170 Japanese men (age 20-79 yr). CRF was assessed by measuring maximal oxygen uptake (Vo2max), and subjects were divided into low-fitness and high-fitness groups according to the reference Vo2max value for health promotion in Japan. We analyzed 19 single nucleotide polymorphisms (SNPs) associated with TG, LDL-C, or HDL-C levels. Based on these SNPs, we calculated three genetic risk scores (GRSs: TG-GRS, LDL-GRS, and HDL-GRS), and subjects were divided into low, middle, and high groups according to the tertile for each GRS. Serum TG levels of low-fitness individuals were higher in the high and middle TG-GRS groups than in the low TG-GRS group (P < 0.01 and P < 0.05, respectively), whereas no differences were detected in the TG levels of high-fitness individuals among the TG-GRS groups. In contrast, the high LDL-GRS group had higher LDL-C levels than did the low LDL-GRS group, and HDL-C levels were lower in the high HDL-GRS group than in the low HDL-GRS group regardless of the fitness level (P < 0.05). These results suggest that high CRF attenuates polygenic risk for hypertriglyceridemia; however, high CRF may not modify the polygenic risk associated with high LDL-C and low HDL-C levels in Japanese men.
高心肺适能（CRF）与血脂异常风险降低相关；然而，血脂水平也受个体基因变异影响。我们进行了一项横断面研究，以确定CRF是否会改变血脂异常的多基因风险。对170名日本男性（年龄20 - 79岁）测量了血清甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）水平。通过测量最大摄氧量（Vo2max）评估CRF，并根据日本促进健康的Vo2max参考值将受试者分为低适能组和高适能组。我们分析了与TG、LDL-C或HDL-C水平相关的19个单核苷酸多态性（SNP）。基于这些SNP，我们计算了三个遗传风险评分（GRS：TG-GRS、LDL-GRS和HDL-GRS），并根据每个GRS的三分位数将受试者分为低、中、高组。低适能个体的血清TG水平在高和中TG-GRS组中高于低TG-GRS组（分别为P < 0.01和P < 0.05），而在高适能个体的TG水平中，TG-GRS组之间未检测到差异。相反，高LDL-GRS组的LDL-C水平高于低LDL-GRS组，无论适能水平如何，高HDL-GRS组的HDL-C水平低于低HDL-GRS组（P < 0.05）。这些结果表明，高CRF可减轻高甘油三酯血症的多基因风险；然而，高CRF可能不会改变日本男性中与高LDL-C和低HDL-C水平相关的多基因风险。
