Department of Clinical Health Science, Tokai University School of Medicine, Japan.
Intern Med. 2020 Nov 1;59(21):2661-2669. doi: 10.2169/internalmedicine.4954-20. Epub 2020 Jul 14.
Objective The triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio is related to insulin resistance (IR). However, information about whether or not the TG/HDL-C ratio is associated with low-density lipoprotein (LDL) subclasses in the Japanese population is limited. Methods In total, 1,068 Japanese subjects who underwent an annual health examination and who were not taking medications were recruited. The association between the TG/HDL-C ratio and LDL subclasses was investigated using correlation, multiple regression, and receiver operating characteristic analyses. Results A correlation analysis revealed that both malondialdehyde-modified low-density lipoprotein (MDA-LDL) and small dense low-density lipoprotein cholesterol (sdLDL-C) were positively associated with the TG/HDL-C ratio. Furthermore, a multiple linear regression analysis revealed that the TG/HDL-C ratio was positively associated with MDA-LDL and sdLDL-C in both men and women. The multiple logistic regression analysis also revealed that the TG/HDL-C ratio was positively associated with the upper tertile of MDA-LDL and sdLDL-C in men and women. The LDL-C levels increased with the increasing TG/HDL-C ratio. The MDA-LDL and sdLDL-C are known to be positively associated with LDL-C. However, within the same LDL-C range, both MDA-LDL and sdLDL-C levels increased with the TG/HDL-C ratio, except for MDA-LDL levels in the LDL-C <112 mg/dL group in women. These results further supported the notion that the TG/HDL-C ratio was positively associated with the MDA-LDL and sdLDL-C levels, especially in the higher LDL-C range, in both men and women. The optimal cut-off points of the TG/HDL-C ratio for the upper tertile of MDA-LDL and sdLDL-C were 1.85 and 2.03 in men and 0.88 and 1.30 in women, respectively. Conclusion The TG/HDL-C ratio is positively associated with MDA-LDL and sdLDL-C in Japanese subjects. The relationship was particularly notable in subjects with high LDL-C levels.
甘油三酯（TG）/高密度脂蛋白胆固醇（HDL-C）比值与胰岛素抵抗（IR）有关。然而，关于该比值与日本人群中低密度脂蛋白（LDL）亚类的关系的信息有限。
共纳入 1068 名接受年度体检且未服用药物的日本受试者。采用相关分析、多元回归分析和受试者工作特征分析探讨 TG/HDL-C 比值与 LDL 亚类的关系。
相关性分析显示，丙二醛修饰的 LDL（MDA-LDL）和小而密 LDL 胆固醇（sdLDL-C）均与 TG/HDL-C 比值呈正相关。此外，多元线性回归分析显示，TG/HDL-C 比值与男性和女性的 MDA-LDL 和 sdLDL-C 均呈正相关。多因素逻辑回归分析也显示，TG/HDL-C 比值与男性和女性 MDA-LDL 和 sdLDL-C 的上三分之一呈正相关。随着 TG/HDL-C 比值的增加，LDL-C 水平也随之升高。MDA-LDL 和 sdLDL-C 与 LDL-C 呈正相关。然而，在相同的 LDL-C 范围内，除了女性 LDL-C<112mg/dL 组的 MDA-LDL 水平外，MDA-LDL 和 sdLDL-C 水平均随着 TG/HDL-C 比值的增加而增加。这些结果进一步证实，TG/HDL-C 比值与 MDA-LDL 和 sdLDL-C 水平呈正相关，尤其是在男性和女性的较高 LDL-C 范围内。男性和女性 MDA-LDL 和 sdLDL-C 上三分之一的 TG/HDL-C 比值的最佳截断点分别为 1.85 和 2.03，0.88 和 1.30。
在日本受试者中，TG/HDL-C 比值与 MDA-LDL 和 sdLDL-C 呈正相关。在 LDL-C 水平较高的受试者中，这种关系更为显著。
