Ghannad Masoud Sabouri, Solgi Ghasem, Hashemi Sayed Hamid, Zebarjady-Bagherpour Javad, Hemmatzadeh Ali, Hajilooi Mehrdad
Departments of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan.
Departments of Immunology and Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan.
Iran J Microbiol. 2013 Sep;5(3):272-7.
Encephalitis can cause a severe public health problem. The main aim of this research was to evaluate the medical laboratory results of patients with Herpes Simplex Virus (HSV) encephalitis.
Diagnosis of encephalitis for these patients was firstly based on a clinical profile for Herpes Simplex Encephalitis (HSE), plus either a detected HSV1&2-DNA by PCR in CSF or brain neuro-imaging results.
Molecular testing on CSF showed that 15 patients (15%) had HSV infection, 5 patients (5%) had Varicella Zoster Virus (VZV) and one case was positive for Human Immunodeficiency Virus (HIV)-RNA in CSF. The cause of encephalitis in 79 out of 100 patients (79%) was unknown. The comparison of CSF analysis in HSV positives and negatives showed a significant increase of glucose and protein levels in HSV positives than negatives. The mortality rate was 46.6% (7/15) in patients with HSV encephalitis compared to 11.4% (10/85) in non-HSV encephalitis (P = 0.003).
In the current study, 15% of cases were diagnosed as having HSV.
脑炎可引发严重的公共卫生问题。本研究的主要目的是评估单纯疱疹病毒（HSV）脑炎患者的医学检验结果。
这些患者的脑炎诊断首先基于单纯疱疹性脑炎（HSE）的临床特征，以及脑脊液中通过聚合酶链反应（PCR）检测到的HSV1&2-DNA或脑部神经影像学结果。
脑脊液的分子检测显示，15名患者（15%）感染了HSV，5名患者（5%）感染了水痘带状疱疹病毒（VZV），1例脑脊液中的人类免疫缺陷病毒（HIV）-RNA呈阳性。100名患者中有79名（79%）的脑炎病因不明。HSV阳性和阴性患者的脑脊液分析比较显示，HSV阳性患者的葡萄糖和蛋白质水平显著高于阴性患者。HSV脑炎患者的死亡率为46.6%（7/15），而非HSV脑炎患者的死亡率为11.4%（10/85）（P = 0.003）。
在本研究中，15%的病例被诊断为患有HSV。
