阿拉伯联合酋长国阻塞性睡眠呼吸暂停患者的肥胖低通气综合征：一项回顾性横断面研究。
Obesity hypoventilation syndrome in obstructive sleep apnea patients in the United Arab Emirates: a retrospective cross-sectional study.
作者信息
Alzaabi Ashraf, Fizal Salahudeen, Moilothkandy Rafeek, Mahboub Bassam, Nagelkerke Nico
机构信息
Respirology Division, Zayed Military Hospital, Abu Dhabi, UAE.
Respirology Division, University of Sharjah, Sharjah, UAE.
出版信息
JRSM Short Rep. 2013 Nov 21;4(12):2042533313510156. doi: 10.1177/2042533313510156. eCollection 2013 Dec.
OBJECTIVES
To estimate the frequency of symptoms of obesity hypoventilation syndrome (OHS) in patients with obstructive sleep apnoea (OSA) and to evaluate comorbidities associated with OHS.
DESIGN
Retrospective study based on patients' medical records and on further sleep tests performed in the study centre during the inclusion visit.
SETTING
Respiratory Care Unit and Sleep Disorder Centre of the Zayed Military Hospital United Arab Emirates.
PARTICIPANTS
All patients referred to the study centre for a suspicion of sleep-disordered breathing.
MAIN OUTCOME MEASURES
Prevalence of OSA and OSA + OHS and comorbidities in patients with OSA and OHS.
RESULTS
A total of 212 adult patients participated in the study. Of these, 107 patients (50.5% [43.8-57.1% CI 95%]) fulfilled diagnostic criteria for OSA, and the majority were men (79.4%). Among patients with OSA, 18 patients (16.8% [10.8-25.1% CI 95%]) fulfilled diagnostic criteria for OHS. In this group, women were more frequently affected than men (31.8% [7/22] vs. 12.9% [11/85], respectively; p = 0.03) and tended to be older than affected men, with a mean age of 55 ± 10.6 years versus 46 ± 13 for men. After adjustment for gender, OHS was significantly associated with hypertension (OR = 3.5; p = 0.03), diabetes mellitus (OR = 4.6; p = 0.02), ischaemic heart disease (OR = 5.1; p = 0.04) and pulmonary hypertension (OR = 16.1; p = 0.001).
CONCLUSION
OHS is a common condition in obese patients in the UAE and is associated with an increased risk of cardiovascular comorbidities and diabetes.
目的
评估阻塞性睡眠呼吸暂停（OSA）患者中肥胖低通气综合征（OHS）症状的发生频率，并评估与OHS相关的合并症。
设计
基于患者病历及在纳入研究访视期间于研究中心进行的进一步睡眠测试的回顾性研究。
地点
阿拉伯联合酋长国扎耶德军事医院呼吸护理科及睡眠障碍中心。
参与者
所有因疑似睡眠呼吸障碍而转诊至研究中心的患者。
主要观察指标
OSA、OSA + OHS的患病率以及OSA和OHS患者的合并症。
结果
共有212名成年患者参与了该研究。其中，107名患者（50.5% [43.8 - 57.1%，95%置信区间]）符合OSA诊断标准，且大多数为男性（79.4%）。在OSA患者中，18名患者（16.8% [10.8 - 25.1%，95%置信区间]）符合OHS诊断标准。在这组患者中，女性比男性更易受影响（分别为31.8% [7/22] 对12.9% [11/85]；p = 0.03），且受影响女性的年龄往往比男性大，平均年龄为55 ± 10.6岁，而男性为46 ± 13岁。在对性别进行调整后，OHS与高血压（OR = 3.5；p = 0.03）、糖尿病（OR = 4.6；p = 0.02）、缺血性心脏病（OR = 5.1；p = 0.04）和肺动脉高压（OR = 16.1；p = 0.001）显著相关。
结论
在阿联酋，OHS在肥胖患者中很常见，且与心血管合并症和糖尿病的风险增加相关。
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