Sleep Medicine Fellowship Program, Section of Pulmonary and Critical Care Medicine, University of Chicago, Room W438, Chicago, IL 60637, USA.
Clin Chest Med. 2009 Sep;30(3):467-78, vii-viii. doi: 10.1016/j.ccm.2009.05.004.
Obesity-hypoventilation syndrome (OHS), also historically described as the Pickwickian syndrome, consists of the triad of obesity, sleep disordered breathing, and chronic hypercapnia during wakefulness in the absence of other known causes of hypercapnia. Its exact prevalence is unknown, but it has been estimated that 10% to 20% of obese patients with obstructive sleep apnea have hypercapnia. OHS often remains undiagnosed until late in the course of the disease. Early recognition is important because these patients have significant morbidity and mortality. Effective treatment can lead to significant improvement in patient outcomes, underscoring the importance of early diagnosis. The authors review the definition and epidemiology of OHS, in addition to the current multifaceted understanding of the pathophysiology, and provide useful clinical approaches to diagnosis and treatment.
肥胖低通气综合征（OHS），也有历史地被描述为匹克威克综合征，由肥胖、睡眠呼吸紊乱以及清醒时的慢性高碳酸血症组成，而无其他已知高碳酸血症的原因。其确切的患病率尚不清楚，但据估计，10%至 20%的阻塞性睡眠呼吸暂停肥胖患者存在高碳酸血症。OHS 通常在疾病的后期才被诊断出来。早期识别很重要，因为这些患者有显著的发病率和死亡率。有效的治疗可以显著改善患者的预后，突出了早期诊断的重要性。作者回顾了 OHS 的定义和流行病学，以及目前对其病理生理学的多方面理解，并提供了有用的临床诊断和治疗方法。
