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韩国首例汉赛巴尔通体菌血症病例。

First Case of Bartonella henselae Bacteremia in Korea.

作者信息

Im Jae-Hyoung, Baek Ji Hyeon, Lee Hyun-Jung, Lee Jin-Soo, Chung Moon-Hyun, Kim Mijeong, Lee Sun Myoung, Kang Jae-Seung

机构信息

Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.

Translation Research Center, Inha University School of Medicine, Incheon, Korea.

出版信息

Infect Chemother. 2013 Dec;45(4):446-50. doi: 10.3947/ic.2013.45.4.446. Epub 2013 Dec 27.

Abstract

Bartonella henselae causes cat-scratch disease, bacteremia, and various focal infections. Despite the worldwide occurrence of B. henselae infections, reports in humans are rare in Korea. The clinical manifestation of all 5 previously reported cases was lymphadenopathy. Herein, we report a case of bacteremia in a woman who presented with prolonged fever. B. henselae was isolated from a blood specimen by cell culture. Conventional polymerase chain reaction amplification and sequencing of the 16S-23S rRNA intergenic space region confirmed the isolate to be B. henselae. The patient had no underlying immunocompromising conditions and no recent exposure to animals. She was successfully managed with a combination of doxycycline and hydroxychloroquine.

摘要

亨氏巴尔通体可引起猫抓病、菌血症及各种局灶性感染。尽管亨氏巴尔通体感染在全球范围内都有发生,但在韩国人类感染病例的报道却很罕见。此前报道的所有5例病例的临床表现均为淋巴结病。在此,我们报告一例出现长期发热的女性菌血症病例。通过细胞培养从血液标本中分离出亨氏巴尔通体。对16S - 23S rRNA基因间隔区进行常规聚合酶链反应扩增和测序,证实分离株为亨氏巴尔通体。该患者没有潜在的免疫功能低下状况,近期也未接触过动物。她通过强力霉素和羟氯喹联合治疗成功康复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b772/3902810/e89a51afad3a/ic-45-446-g001.jpg

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