Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria 21523, Egypt.
Biomed Res Int. 2022 Aug 2;2022:1546734. doi: 10.1155/2022/1546734. eCollection 2022.
Lornoxicam is a potent oxicam-class nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and antipyretic effects. Its impacts on many biological functions are not fully understood. We measured various biomarkers in male albino rats provided an oral aqueous ginger extract before IM administration of therapeutic and 2× the therapeutic doses of lornoxicam. The aqueous ginger plant extract was characterized by mass spectroscopy, and its effects were determined by examining free radical scavenging activity, blood parameters, renal and hepatic function, semen quality, proinflammatory cytokines, antioxidant markers, and histopathology. Rats administered lornoxicam had significantly higher liver and kidney function biomarker values, TNF-, interleukin-6, and sperm abnormalities than the control rats. The overall erythrocyte count, packed cell volume, prostaglandin, and sperm counts were all considerably lower in the experimental animals. Histological changes were found in the liver, spleen, and testes of rats administered lornoxicam alone. In rats, pretreatment with ginger extract reduced the majority of the negative effects of conventional and high dosages of lornoxicam.
氯诺昔康是一种强效昔布类非甾体抗炎药（NSAID），具有镇痛、抗炎和退热作用。其对许多生物功能的影响尚未完全了解。我们在雄性白化大鼠中进行了测量，这些大鼠在肌内给予治疗剂量和 2 倍治疗剂量的氯诺昔康之前，口服给予水性姜提取物。通过质谱对水性姜植物提取物进行了表征，并通过检查自由基清除活性、血液参数、肾功能和肝功能、精液质量、促炎细胞因子、抗氧化标志物和组织病理学来确定其作用。与对照组大鼠相比，给予氯诺昔康的大鼠的肝肾功能生物标志物值、TNF-α、白细胞介素-6 和精子异常明显更高。实验动物的总红细胞计数、红细胞压积、前列腺素和精子计数都明显降低。单独给予氯诺昔康的大鼠的肝脏、脾脏和睾丸中发现了组织学变化。在大鼠中，姜提取物预处理可减轻常规和高剂量氯诺昔康的大多数负面影响。
