Sadek S, Dayem H A, Owunwanne A, Yacoub T
Nuclear Medicine Department, Faculty of Medicine, Kuwait University, Safat.
Nucl Med Commun. 1987 Jun;8(6):395-405. doi: 10.1097/00006231-198706000-00002.
The usefulness of 99Tcm hydroxyethyl starch (99Tcm HES) has been evaluated for visualization of lymphatic channels and lymph nodes. 99Tcm HES was prepared with a labelling efficiency higher than 95%. Its usefulness for imaging lymphatic channels and lymph nodes were compared to 99Tcm human serum albumin (99Tcm HSA), 99Tcm dextran (99Tcm DXT) and 99Tcm sulphur micro colloid (99Tcm SMC) in rabbits. 99Tcm HES showed a good visualization of lymphatic channels and lymph nodes and it had the highest clearance rate from the injection site (P less than 0.01). 99Tcm HES showed higher uptake by the nodes than 99Tcm DXT (P less than 0.001) at 90 min post injection. The concentration of 99Tcm HES in the lymphatic channels was higher than that of 99Tcm SMC at 90 min post injection (P less than 0.001). Preliminary studies of 99Tcm HES in humans provided high-quality lymphoscintigrams of the leg, and the pelvic and para aortic lymph nodes in less than 10 min post injection. In addition, partially and completely obstructed lymphatics could be differentiated from the normal one. Hence 99Tcm HES is a potential radiopharmaceutical for visualization of lymphatic channels and nodes.
已对锝-99m标记的羟乙基淀粉（99Tcm HES）用于淋巴管和淋巴结显影的效用进行了评估。制备的99Tcm HES标记效率高于95%。在兔体内，将其用于淋巴管和淋巴结成像的效用与锝-99m人血清白蛋白（99Tcm HSA）、锝-99m葡聚糖（99Tcm DXT）和锝-99m硫微胶体（99Tcm SMC）进行了比较。99Tcm HES对淋巴管和淋巴结显示出良好的显影效果，并且它从注射部位的清除率最高（P小于0.01）。注射后90分钟时，99Tcm HES在淋巴结中的摄取高于99Tcm DXT（P小于0.001）。注射后90分钟时，99Tcm HES在淋巴管中的浓度高于99Tcm SMC（P小于0.001）。对人体进行的99Tcm HES初步研究在注射后不到10分钟就提供了高质量的腿部、盆腔和腹主动脉旁淋巴结淋巴闪烁图。此外，可区分部分和完全阻塞的淋巴管与正常淋巴管。因此，99Tcm HES是一种用于淋巴管和淋巴结显影的潜在放射性药物。
