Juma N, Andrey T, Ege G N
Br J Radiol. 1985 Apr;58(688):325-30. doi: 10.1259/0007-1285-58-688-325.
To determine its suitability as a lymph node imaging agent, 99Tcm dextran (99TcmDx) was compared with 99Tcm antimony sulphide colloid (99TcmSb2S3) in rabbits and dogs. In two groups of five rabbits each, absorption from the interstitial injection site, popliteal lymph node sequestration and total body uptake and distribution of both agents were determined. In three dogs, both agents were studied simultaneously, 99TcmDx and 99TcmSb2S3 being injected into the left and right hind feet respectively; therefore, only popliteal lymph node sequestration and image qualities were evaluated. Uptake curves in the rabbits indicated that total body uptake of 99TcmDx is faster and greater than that of 99TcmSb2S3. In spite of rapid lymph node uptake rates, total popliteal lymph node sequestration of 99TcmDx is significantly lower than that observed for 99TcmSb2S3. While lymph node uptake of 99TcmDx in dogs is higher than in rabbits, disparity between the two agents persists and is demonstrable in the image in both species. Reduced lymph node sequestration of 99TcmDx may result from its non-colloidal nature as well as its instability, both of which render this agent unsuitable for imaging pathological features of lymph nodes although its rapid absorption and distribution may be ideal characteristics for the study of lymphatic kinetics.
为确定99锝标记右旋糖酐（99TcmDx）作为淋巴结显像剂的适用性，将其与99锝标记硫化锑胶体（99TcmSb2S3）在兔和犬体内进行了比较。在两组各五只兔中，测定了两种显像剂经间质注射部位的吸收、腘窝淋巴结潴留以及全身摄取和分布情况。在三只犬中，同时对两种显像剂进行研究，将99TcmDx和99TcmSb2S3分别注入左右后足；因此，仅评估了腘窝淋巴结潴留和图像质量。兔的摄取曲线表明，99TcmDx的全身摄取比99TcmSb2S3更快且更多。尽管淋巴结摄取率较快，但99TcmDx的腘窝淋巴结总潴留明显低于99TcmSb2S3。虽然犬体内99TcmDx的淋巴结摄取高于兔，但两种显像剂之间的差异仍然存在，且在两个物种的图像中均可见。99TcmDx淋巴结潴留减少可能是由于其非胶体性质及其不稳定性，尽管其快速吸收和分布可能是研究淋巴动力学的理想特性，但这两个因素均使其不适用于淋巴结病理特征的显像。
