血管紧张素转换酶插入/缺失（I/D）多态性与糖尿病肾病
ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy.
作者信息
Rahimi Zohreh
机构信息
Medical Biology Research Center and Department of Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
J Nephropathol. 2012 Oct;1(3):143-51. doi: 10.5812/nephropathol.8109. Epub 2012 Oct 1.
Abstract
CONTEXT
Angiotensin converting enzyme (ACE) gene encodes ACE, a key component of renin angiotensin system (RAS), plays an important role in blood pressure homeostasis by generating the vasoconstrictor peptide angiotensin II.
EVIDENCE ACQUISITIONS
Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.
RESULTS
The presence of ACE insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with the highest systemic and renal ACE levels compared with the lowest ACE activity in carriers of II genotype.
CONCLUSIONS
In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Also, association between ACE I/D polymorphism and response to ACE inhibitor and angiotensin II receptor antagonists will be reviewed. Further, synergistic effect of this polymorphism and variants of some genes on the risk of development of diabetic nephropathy will be discussed.
摘要
背景
血管紧张素转换酶（ACE）基因编码ACE，肾素血管紧张素系统（RAS）的关键组成部分，通过生成血管收缩肽血管紧张素II在血压稳态中起重要作用。
证据获取
检索了开放获取期刊目录（DOAJ）、谷歌学术、PubMed（美国国立医学图书馆）、LISTA（EBSCO）和科学引文索引。
结果
ACE插入/缺失（I/D）多态性的存在影响ACE的血浆水平。与II基因型携带者中最低的ACE活性相比，ACE DD基因型与最高的全身和肾脏ACE水平相关。
结论
本综述重点研究了不同人群中ACE I/D多态性及其对糖尿病肾病发病和进展风险的影响。此外，还将综述ACE I/D多态性与ACE抑制剂和血管紧张素II受体拮抗剂反应之间的关联。此外，还将讨论这种多态性与某些基因变体对糖尿病肾病发生风险的协同作用。
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本文引用的文献
1
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J Renin Angiotensin Aldosterone Syst. 2013 Jun;14(2):174-80. doi: 10.1177/1470320312448950. Epub 2012 Jun 19.
2
Meta-analysis of the relationship between ACE I/D gene polymorphism and end-stage renal disease in patients with diabetic nephropathy.
Nephrology (Carlton). 2012 Jul;17(5):480-7. doi: 10.1111/j.1440-1797.2012.01592.x.
3
Concomitant presence of endothelial nitric oxide 894T and angiotensin II-converting enzyme D alleles are associated with diabetic nephropathy in a Kurdish population from Western Iran.
Nephrology (Carlton). 2012 Feb;17(2):175-81. doi: 10.1111/j.1440-1797.2011.01533.x.
4
Interaction of MTHFR 1298C with ACE D allele augments the risk of diabetic nephropathy in Western Iran.
DNA Cell Biol. 2012 Apr;31(4):553-9. doi: 10.1089/dna.2011.1364. Epub 2011 Sep 23.
5
Association between genetic polymorphism of the angiotensin-converting enzyme and diabetic nephropathy: a meta-analysis comprising 26,580 subjects.
J Renin Angiotensin Aldosterone Syst. 2012 Mar;13(1):161-74. doi: 10.1177/1470320311417655. Epub 2011 Aug 2.
6
Preeclampsia in North Indian women: the contribution of genetic polymorphisms.
J Obstet Gynaecol Res. 2011 Oct;37(10):1335-41. doi: 10.1111/j.1447-0756.2010.01523.x. Epub 2011 May 12.
7
Role of the renin angiotensin system in diabetic nephropathy.
World J Diabetes. 2010 Nov 15;1(5):141-5. doi: 10.4239/wjd.v1.i5.141.
8
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9
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10
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