Rahimi Zohreh
Medical Biology Research Center and Department of Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Nephropathol. 2012 Oct;1(3):143-51. doi: 10.5812/nephropathol.8109. Epub 2012 Oct 1.
Angiotensin converting enzyme (ACE) gene encodes ACE, a key component of renin angiotensin system (RAS), plays an important role in blood pressure homeostasis by generating the vasoconstrictor peptide angiotensin II.
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The presence of ACE insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with the highest systemic and renal ACE levels compared with the lowest ACE activity in carriers of II genotype.
In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Also, association between ACE I/D polymorphism and response to ACE inhibitor and angiotensin II receptor antagonists will be reviewed. Further, synergistic effect of this polymorphism and variants of some genes on the risk of development of diabetic nephropathy will be discussed.
血管紧张素转换酶（ACE）基因编码ACE，肾素血管紧张素系统（RAS）的关键组成部分，通过生成血管收缩肽血管紧张素II在血压稳态中起重要作用。
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ACE插入/缺失（I/D）多态性的存在影响ACE的血浆水平。与II基因型携带者中最低的ACE活性相比，ACE DD基因型与最高的全身和肾脏ACE水平相关。
本综述重点研究了不同人群中ACE I/D多态性及其对糖尿病肾病发病和进展风险的影响。此外，还将综述ACE I/D多态性与ACE抑制剂和血管紧张素II受体拮抗剂反应之间的关联。此外，还将讨论这种多态性与某些基因变体对糖尿病肾病发生风险的协同作用。
