Jahir Tahmina, Hossain S M Sadaf, Risal Ruby, Schmidt Marie, Enriquez Danilo, Bagum Mobasera
Pulmonary and Critical Care Medicine, Interfaith Medical Center, Brooklyn, USA.
Internal Medicine, Jamaica Hospital Medical Center, Richmond Hill, USA.
Cureus. 2021 Nov 3;13(11):e19236. doi: 10.7759/cureus.19236. eCollection 2021 Nov.
Cocaine is a powerfully addictive recreational drug that is extracted from the leaves of the plant native to Central and South America. It is a widely abused substance, despite being banned since the early 19th century due to fatalities. Cocaine may result in acute kidney injury (AKI) by different mechanisms, but acute interstitial nephritis (AIN) is scarcely recognized as the cause of acute kidney injury (AKI). Here, we present a case of AKI from both AIN and acute tubular necrosis (ATN) following cocaine insufflation. The purpose of this article is to review the rare but significant association of AIN associated with cocaine use. The nature of the treatment of cocaine-related kidney disease may differ from other causes of acute kidney insult. Prompt recognition of the underlying cause of renal dysfunction is vital for this group of patients to prevent the rapid deterioration of renal function.
可卡因是一种极易成瘾的消遣性毒品，它是从原产于中南美洲的植物叶子中提取出来的。尽管自19世纪初因致死事件而被禁止，但它仍是一种被广泛滥用的物质。可卡因可通过不同机制导致急性肾损伤（AKI），但急性间质性肾炎（AIN）很少被认为是急性肾损伤（AKI）的病因。在此，我们报告一例因吸入可卡因后出现AIN和急性肾小管坏死（ATN）导致的AKI病例。本文旨在综述与可卡因使用相关的罕见但重要的AIN关联。可卡因相关肾病的治疗性质可能与急性肾损伤的其他病因不同。对于这组患者，迅速识别肾功能障碍的潜在病因对于防止肾功能迅速恶化至关重要。
