通过高速原子力显微镜拍摄生物分子过程。 - Suppr | 超能文献

文献检索
文档翻译
深度研究
学术资讯

Zotero 插件

邀请有礼
套餐&价格
历史记录

应用&插件

Zotero 插件浏览器插件 Mac 客户端 Windows 客户端微信小程序

定价

高级版会员购买积分包购买API积分包

服务

文献检索文档翻译深度研究 API 文档 MCP 服务

关于我们

关于 Suppr 公司介绍联系我们用户协议隐私条款

关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Filming biomolecular processes by high-speed atomic force microscopy.

作者信息

Ando Toshio, Uchihashi Takayuki, Scheuring Simon

机构信息

Department of Physics, and ‡Bio-AFM Frontier Research Center, Kanazawa University , Kakuma-machi, Kanazawa 920-1192, Japan.

出版信息

Chem Rev. 2014 Mar 26;114(6):3120-88. doi: 10.1021/cr4003837. Epub 2014 Jan 30.

DOI:10.1021/cr4003837

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4076042/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/b02d1d542fb5/cr-2013-003837_0055.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/13456ae2cf44/cr-2013-003837_0003.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/d855cab9335d/cr-2013-003837_0005.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/676118d2f73c/cr-2013-003837_0007.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/712edc5b50d6/cr-2013-003837_0008.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/73a630994b0b/cr-2013-003837_0009.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/3f70f7748f8a/cr-2013-003837_0011.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/1b02a16dced0/cr-2013-003837_0012.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/edca0a83e4d1/cr-2013-003837_0013.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/087133d3d3ff/cr-2013-003837_0014.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/49b7218f20bc/cr-2013-003837_0016.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/f0c1cbf8cb31/cr-2013-003837_0017.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/b2b2d4f78418/cr-2013-003837_0018.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/0d6d5996c7b9/cr-2013-003837_0019.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/720fdc3bdb5e/cr-2013-003837_0020.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/52e8cf8052c3/cr-2013-003837_0021.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/0521024ed551/cr-2013-003837_0022.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/98c05114d140/cr-2013-003837_0023.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/83a7c7c3bb69/cr-2013-003837_0024.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/90f4c4c5ed40/cr-2013-003837_0025.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/0a0dbccb8a0d/cr-2013-003837_0026.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/7daa96984232/cr-2013-003837_0027.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/f03edc9b005b/cr-2013-003837_0028.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/0071e7345a52/cr-2013-003837_0029.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/121a63e22f3e/cr-2013-003837_0030.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/a957c6e46c6b/cr-2013-003837_0031.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/eebc9c3c6ac3/cr-2013-003837_0032.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/ce3f618124fe/cr-2013-003837_0033.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/a9c4f6a2956b/cr-2013-003837_0034.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/2518c769cf58/cr-2013-003837_0035.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/5b68fde8647d/cr-2013-003837_0036.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/67ed864a4f84/cr-2013-003837_0037.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/81724e590261/cr-2013-003837_0038.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/f5c1e790afe2/cr-2013-003837_0039.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/1a268a8cd4a5/cr-2013-003837_0040.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/13c0b339fc9e/cr-2013-003837_0041.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/89cc56ddb866/cr-2013-003837_0042.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/70c502461efc/cr-2013-003837_0043.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/1b9b54d7b544/cr-2013-003837_0044.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/886320382e7a/cr-2013-003837_0045.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/6a39e63d5c87/cr-2013-003837_0046.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/7739b0e0e804/cr-2013-003837_0047.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/084270ee6a11/cr-2013-003837_0048.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/2d7a2750c1aa/cr-2013-003837_0049.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/636208fc3dff/cr-2013-003837_0050.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/659482a93d68/cr-2013-003837_0051.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/0b8c024e4af2/cr-2013-003837_0052.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/6ea1a1286f42/cr-2013-003837_0053.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/aa473019c400/cr-2013-003837_0054.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/b02d1d542fb5/cr-2013-003837_0055.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/13456ae2cf44/cr-2013-003837_0003.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/d855cab9335d/cr-2013-003837_0005.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/676118d2f73c/cr-2013-003837_0007.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/712edc5b50d6/cr-2013-003837_0008.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/73a630994b0b/cr-2013-003837_0009.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/3f70f7748f8a/cr-2013-003837_0011.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/1b02a16dced0/cr-2013-003837_0012.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/edca0a83e4d1/cr-2013-003837_0013.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/087133d3d3ff/cr-2013-003837_0014.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/49b7218f20bc/cr-2013-003837_0016.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/f0c1cbf8cb31/cr-2013-003837_0017.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/b2b2d4f78418/cr-2013-003837_0018.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/0d6d5996c7b9/cr-2013-003837_0019.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/720fdc3bdb5e/cr-2013-003837_0020.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/52e8cf8052c3/cr-2013-003837_0021.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/0521024ed551/cr-2013-003837_0022.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/98c05114d140/cr-2013-003837_0023.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/83a7c7c3bb69/cr-2013-003837_0024.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/90f4c4c5ed40/cr-2013-003837_0025.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/0a0dbccb8a0d/cr-2013-003837_0026.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/7daa96984232/cr-2013-003837_0027.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/f03edc9b005b/cr-2013-003837_0028.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/0071e7345a52/cr-2013-003837_0029.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/121a63e22f3e/cr-2013-003837_0030.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/a957c6e46c6b/cr-2013-003837_0031.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/eebc9c3c6ac3/cr-2013-003837_0032.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/ce3f618124fe/cr-2013-003837_0033.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/a9c4f6a2956b/cr-2013-003837_0034.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/2518c769cf58/cr-2013-003837_0035.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/5b68fde8647d/cr-2013-003837_0036.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/67ed864a4f84/cr-2013-003837_0037.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/81724e590261/cr-2013-003837_0038.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/f5c1e790afe2/cr-2013-003837_0039.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/1a268a8cd4a5/cr-2013-003837_0040.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/13c0b339fc9e/cr-2013-003837_0041.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/89cc56ddb866/cr-2013-003837_0042.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/70c502461efc/cr-2013-003837_0043.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/1b9b54d7b544/cr-2013-003837_0044.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/886320382e7a/cr-2013-003837_0045.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/6a39e63d5c87/cr-2013-003837_0046.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/7739b0e0e804/cr-2013-003837_0047.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/084270ee6a11/cr-2013-003837_0048.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/2d7a2750c1aa/cr-2013-003837_0049.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/636208fc3dff/cr-2013-003837_0050.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/659482a93d68/cr-2013-003837_0051.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/0b8c024e4af2/cr-2013-003837_0052.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/6ea1a1286f42/cr-2013-003837_0053.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/aa473019c400/cr-2013-003837_0054.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f3/4076042/b02d1d542fb5/cr-2013-003837_0055.jpg

相似文献

1

Filming biomolecular processes by high-speed atomic force microscopy.通过高速原子力显微镜拍摄生物分子过程。

Chem Rev. 2014 Mar 26;114(6):3120-88. doi: 10.1021/cr4003837. Epub 2014 Jan 30.

2

Molecular machines directly observed by high-speed atomic force microscopy.高速原子力显微镜直接观察到的分子机器。

FEBS Lett. 2013 Apr 17;587(8):997-1007. doi: 10.1016/j.febslet.2012.12.024. Epub 2013 Jan 11.

3

Molecular rotary motors.分子旋转马达

Science. 1999 Nov 26;286(5445):1687-8. doi: 10.1126/science.286.5445.1687.

4

Guide to video recording of structure dynamics and dynamic processes of proteins by high-speed atomic force microscopy.高速原子力显微镜记录结构动力学和蛋白质动态过程的指南。

Nat Protoc. 2012 May 24;7(6):1193-206. doi: 10.1038/nprot.2012.047.

5

Motor myosin V caught on video: foot stomping in biology.视频捕捉到的肌球蛋白V：生物学中的“跺脚”现象

Biopolymers. 2011 Feb;95(2):v. doi: 10.1002/bip.21569.

6

Mechanical rotation of the c subunit oligomer in ATP synthase (F0F1): direct observation.ATP合酶（F0F1）中c亚基寡聚体的机械旋转：直接观察

Science. 1999 Nov 26;286(5445):1722-4. doi: 10.1126/science.286.5445.1722.

7

Structural biology. Proton-powered turbine of a plant motor.结构生物学。植物马达的质子驱动涡轮机。

Nature. 2000 May 25;405(6785):418-9. doi: 10.1038/35013148.

8

ATP synthase. Is revolution effective?ATP合酶。旋转是否有效？

EMBO Rep. 2000 Sep;1(3):223-4. doi: 10.1093/embo-reports/kvd062.

9

Local probe techniques.局部探针技术。

Methods Cell Biol. 2002;68:1-31. doi: 10.1016/s0091-679x(02)68002-1.

10

How Fo-ATPase generates rotary torque.F型ATP酶如何产生旋转扭矩。

Philos Trans R Soc Lond B Biol Sci. 2000 Apr 29;355(1396):523-8. doi: 10.1098/rstb.2000.0593.

引用本文的文献

1

Direct Observation of Secondary Nucleation in Huntingtin Amyloid Formation by High-Speed Atomic Force Microscopy.通过高速原子力显微镜直接观察亨廷顿蛋白淀粉样蛋白形成过程中的二次成核

J Am Chem Soc. 2025 Jun 25;147(25):21973-21984. doi: 10.1021/jacs.5c05571. Epub 2025 Jun 12.

2

Mechanics and disease of heart cells/cardiomyocytes explored through atomic force microscopy: present and future.通过原子力显微镜探索心脏细胞/心肌细胞的力学与疾病：现状与未来

Biophys Rev. 2025 Apr 9;17(2):347-358. doi: 10.1007/s12551-025-01307-9. eCollection 2025 Apr.

3

Closing the gap: Nonviral TFAMoplex transfection boosted by bZIP domains compared to AAV-mediated transduction.

本文引用的文献

1

Solid supported lipid bilayers: From biophysical studies to sensor design.固体支撑脂质双层膜：从生物物理研究到传感器设计

Surf Sci Rep. 2006 Nov 15;61(10):429-444. doi: 10.1016/j.surfrep.2006.06.001. Epub 2006 Sep 25.

2

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.GROMACS 4：高效、负载均衡和可扩展的分子模拟算法。

J Chem Theory Comput. 2008 Mar;4(3):435-47. doi: 10.1021/ct700301q.

3

State-of-the-art high-speed atomic force microscopy for investigation of single-molecular dynamics of proteins.

缩小差距：与腺相关病毒介导的转导相比，bZIP结构域增强非病毒TFAMoplex转染

Mol Ther Nucleic Acids. 2025 Mar 27;36(2):102526. doi: 10.1016/j.omtn.2025.102526. eCollection 2025 Jun 10.

4

Molecular-level insights into the supramolecular gelation mechanism of urea derivative.对尿素衍生物超分子凝胶化机制的分子水平洞察。

Nat Commun. 2025 Apr 22;16(1):3758. doi: 10.1038/s41467-025-59032-6.

5

Nanomechanical characterization of soft nanomaterial using atomic force microscopy.使用原子力显微镜对软纳米材料进行纳米力学表征。

Mater Today Bio. 2025 Jan 31;31:101506. doi: 10.1016/j.mtbio.2025.101506. eCollection 2025 Apr.

6

Nano-Scale Video Imaging of Motility Machinery by High-Speed Atomic Force Microscopy.利用高速原子力显微镜对运动机制进行纳米级视频成像。

Biomolecules. 2025 Feb 10;15(2):257. doi: 10.3390/biom15020257.

7

A structural biology compatible file format for atomic force microscopy.一种适用于原子力显微镜的结构生物学兼容文件格式。

Nat Commun. 2025 Feb 15;16(1):1671. doi: 10.1038/s41467-025-56760-7.

8

Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations and its dynamics.跷跷板蛋白：一种可采用相互转换的替代功能构象的蛋白质的设计及其动力学

Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2412117122. doi: 10.1073/pnas.2412117122. Epub 2025 Feb 10.

9

Nanoscale dynamics of Dynamin 1 helices reveals squeeze-twist deformation mode critical for membrane fission.Dynamin 1 螺旋的纳米尺度动力学揭示了对于膜裂变至关重要的挤压-扭曲变形模式。

Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2321514121. doi: 10.1073/pnas.2321514121. Epub 2024 Nov 27.

10

Modeling Conformational Transitions of Biomolecules from Atomic Force Microscopy Images using Normal Mode Analysis.利用正则模态分析从原子力显微镜图像中对生物分子构象转变进行建模。

J Phys Chem B. 2024 Oct 3;128(39):9363-9372. doi: 10.1021/acs.jpcb.4c04189. Epub 2024 Sep 25.

用于研究蛋白质单分子动力学的最先进高速原子力显微镜。

Chem Rev. 2014 Jan 22;114(2):1493-520. doi: 10.1021/cr300253x. Epub 2013 Nov 12.

4

High-speed force spectroscopy unfolds titin at the velocity of molecular dynamics simulations.高速力谱学以分子动力学模拟的速度展开 titin。

Science. 2013 Nov 8;342(6159):741-3. doi: 10.1126/science.1239764.

5

Atomic force microscopy studies of APOBEC3G oligomerization and dynamics.原子力显微镜研究 APOBEC3G 的寡聚化和动力学。

J Struct Biol. 2013 Nov;184(2):217-25. doi: 10.1016/j.jsb.2013.09.008. Epub 2013 Sep 18.

6

High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97.高速原子力显微镜观察 ATP 依赖的 AAA+伴侣 p97 的旋转。

Structure. 2013 Nov 5;21(11):1992-2002. doi: 10.1016/j.str.2013.08.017. Epub 2013 Sep 19.

7

Real-time visualization of assembling of a sphingomyelin-specific toxin on planar lipid membranes.实时可视化鞘磷脂特异性毒素在平面脂膜上的组装。

Biophys J. 2013 Sep 17;105(6):1397-405. doi: 10.1016/j.bpj.2013.07.052.

8

High-speed atomic force microscope combined with single-molecule fluorescence microscope.高速原子力显微镜与单分子荧光显微镜联用

Rev Sci Instrum. 2013 Jul;84(7):073706. doi: 10.1063/1.4813280.

9

A hybrid high-speed atomic force-optical microscope for visualizing single membrane proteins on eukaryotic cells.一种用于可视化真核细胞上单膜蛋白的混合高速原子力-光学显微镜。

Nat Commun. 2013;4:2155. doi: 10.1038/ncomms3155.

10

Subangstrom resolution X-ray structure details aquaporin-water interactions.亚埃分辨率 X 射线结构详细信息水通道蛋白-水相互作用。

Science. 2013 Jun 14;340(6138):1346-1349. doi: 10.1126/science.1234306.