Freitas Ana Carolina Carneiro, Campos Luana, Brandão Thaís Bianca, Cristófaro Marcio, Eduardo Fernanda de Paula, Luiz Ana Claudia, Marques Márcia Martins, Eduardo Carlos de Paula, Simões Alyne
1 Departamento de Biomateriais e Biologia Oral, Faculdade de Odontologia - Universidade de São Paulo , São Paulo, SP, Brazil .
Photomed Laser Surg. 2014 Feb;32(2):81-7. doi: 10.1089/pho.2013.3576. Epub 2014 Jan 29.
Over the last few decades, many studies have focused on the effect of lasers on the management of oral mucositis in oncologic patients treated with chemotherapy and/or radiotherapy. However, the effect of light-emitting diode (LED) has been poorly studied, and was not compared with that of laser phototherapy (LPT). For this reason, the aim of the present study was to clinically compare the effect of these two therapies on chemotherapy-induced oral mucositis (CIOM) and pain.
Forty patients with CIOM were divided into two groups: G1, patients treated with LPT; G2, patients treated with LED. The treatment was administered during 10 consecutive days, with exception of weekends. LPT was applied using an InGaAlP laser (660 nm/40 mW/6.6 J cm-(2)/0.24 J per point/0.036 cm(2) of spot size). LED phototherapy was applied using 0.24 J per point/80 mW/630 nm/1 cm(2) of spot size. CIOM was assessed during each session in accordance to the World Health Organization (WHO) score. The patient self-assessed pain was scored on a visual analog scale (VAS).
The mean VAS and WHO scores were significantly smaller in the LED group (p<0.05). However, both groups required the same number of days to reach score zero for mucositis and pain (p>0.05). Moreover, in the group with severe mucositis (score III), there was a lower frequency of patients with complete healing and pain relief, with the exception of analgesia in G2, in which almost all patients were completely relieved from pain.
These findings suggest that LED therapy is more effective than LPT in the treatment of COIM, with the parameters used in the present study.
在过去几十年中，许多研究聚焦于激光对接受化疗和/或放疗的肿瘤患者口腔黏膜炎管理的影响。然而，发光二极管（LED）的效果研究较少，且未与激光光疗（LPT）进行比较。因此，本研究的目的是临床比较这两种疗法对化疗诱导的口腔黏膜炎（CIOM）和疼痛的影响。
40例CIOM患者分为两组：G1组，接受LPT治疗的患者；G2组，接受LED治疗的患者。治疗连续进行10天，周末除外。使用InGaAlP激光（660nm/40mW/6.6J·cm⁻²/每点0.24J/光斑尺寸0.036cm²）进行LPT。使用每点0.24J/80mW/630nm/光斑尺寸1cm²进行LED光疗。每次治疗时根据世界卫生组织（WHO）评分评估CIOM。患者通过视觉模拟量表（VAS）进行自我疼痛评分。
LED组的平均VAS和WHO评分显著更低（p<0.05）。然而，两组达到口腔黏膜炎和疼痛评分为零所需的天数相同（p>0.05）。此外，在重度口腔黏膜炎（III级评分）组中，完全愈合和疼痛缓解的患者频率较低，但G2组除外，该组几乎所有患者疼痛完全缓解。
这些发现表明，就本研究中使用的参数而言，LED疗法在治疗COIM方面比LPT更有效。
