Lino Maíra Dória Martinez da Costa, Carvalho Fabíola Bastos de, Oliveira Lara Ramalho de, Magalhães Edval Barreto, Pinheiro Antônio Luiz Barbosa, Ramalho Luciana Maria Pedreira
Center of Biophotonics, Dental School, Federal University of Bahia, Salvador, BA, Brazil.
Braz Dent J. 2011;22(2):162-5. doi: 10.1590/s0103-64402011000200013.
Oral mucositis is a harmful side effect of radiotherapy (RT) on the head and neck region. There are encouraging reports on the beneficial aspects of the use of laser light on the treatment of oral mucositis. This paper reports the efficacy of laser phototherapy (LPT) on the treatment of oral mucositis in a patient undergoing RT after surgical removal of a squamous cell carcinoma with osseous invasion of the maxilla. Palatal and commissural lesions were treated with λ660 nm, 40 mW, ∅=4 mm(2), in contact mode, 5 x 2.4 J/cm(2) per point, 14.4 J/cm(2) per session. For treating the lesion on the patient's nasal mucosa, LPT (∅=4 mm(2), λ780 nm, 70 mW, 3 x 2.1 J/cm(2) per point, 6.3 J/cm(2) per session, contact mode) was used on the external area of the nose. A single dose (2.4 J/cm(2)) with the λ660 nm laser, as described before, was applied on the entrance of each nostril. LPT was used 3 times/week during 4 weeks. Treatment results indicate that the use of LPT on oral mucositis was effective and allowed the patient to carry on the RT without interruption. However, long-term and controlled clinical trials are necessary to establish both preventive and curative protocols using LPT.
口腔黏膜炎是头颈部放疗的一种有害副作用。关于使用激光治疗口腔黏膜炎的益处有一些令人鼓舞的报道。本文报告了激光光疗（LPT）对一名上颌骨骨侵犯鳞状细胞癌手术切除后接受放疗患者口腔黏膜炎的治疗效果。腭部和口角病变采用波长660 nm、功率40 mW、光斑直径4 mm²的激光，接触式照射，每点5×2.4 J/cm²，每次照射14.4 J/cm²。为治疗患者鼻黏膜病变，在鼻外部采用LPT（光斑直径4 mm²，波长780 nm，功率70 mW，每点3×2.1 J/cm²，每次照射6.3 J/cm²，接触式照射）。每个鼻孔入口处采用如前所述的波长660 nm激光单剂量（2.4 J/cm²）照射。LPT每周使用3次，共4周。治疗结果表明，LPT治疗口腔黏膜炎有效，使患者能够不间断地进行放疗。然而，需要进行长期且可控的临床试验来制定使用LPT的预防和治疗方案。
