Pina Annick, Sauthier Philippe, Rahimi Kurosh
1Obstetrics & Gynecology Department, Université de Montréal, CHUM, Hôpital Saint-Luc; 2Gynecologic Oncology Division, Obstetrics & Gynecology Department, Université de Montréal, CHUM, Hôpital Notre-Dame; 3Pathology Department, Université de Montréal, CHUM, Hôpital Notre-Dame, Montreal (Quebec), Canada.
J Low Genit Tract Dis. 2015 Jan;19(1):e10-2. doi: 10.1097/LGT.0000000000000010.
Trichoblastomas are rare and benign tumors that arise from rudimentary hair follicles. Presentation varies from superficial plaques to papular or nodular lesions. Trichoblastomas usually arise on the head or neck. A few cases of other vulvar trichoblastic tumors such as trichofibromas and trichoepitheliomas have been reported to this day, but no such report of vulvar trichoblastoma exists.
We report the case of a 61-year-old woman who presented with a vulvar trichoblastoma. The woman presented with a lump of the labium majus. She was managed surgically, first by wide excision of the mass followed by a second surgery consisting of a partial vulvectomy. Because surgical margins were positive and there is a potential for malignant transformation, a third surgery was performed. The margins came back negative. A literature review on trichoblastomas was performed, including its potential for malignant transformation, management, and immunohistochemistry to differentiate it from basal cell carcinoma.
Trichoblastomas are benign tumors that have a potential for malignant transformation. These tumors can present aggressive characteristics. Differential diagnosis from basal cell carcinoma can be difficult but is facilitated using immunohistochemistry.
This is the first case of vulvar trichoblastoma reported in the literature. Although it is a benign tumor, excision with negative margins is recommended because it can be difficult to distinguish from basal cell carcinoma and it has a potential for malignant transformation.
毛母细胞瘤是一种罕见的良性肿瘤，起源于原始毛囊。其表现多样，从浅表斑块到丘疹或结节性病变不等。毛母细胞瘤通常发生在头颈部。迄今为止，已有少数关于其他外阴毛母细胞性肿瘤（如毛发纤维瘤和毛发上皮瘤）的病例报道，但尚无外阴毛母细胞瘤的相关报道。
我们报告了一例61岁患有外阴毛母细胞瘤的女性病例。该女性表现为大阴唇肿块。她接受了手术治疗，首先对肿块进行广泛切除，随后进行了第二次手术，即部分外阴切除术。由于手术切缘阳性且存在恶性转化的可能性，因此进行了第三次手术。切缘结果为阴性。我们对外阴毛母细胞瘤进行了文献综述，包括其恶性转化的可能性、治疗方法以及用于与基底细胞癌鉴别的免疫组织化学。
毛母细胞瘤是具有恶性转化潜能的良性肿瘤。这些肿瘤可呈现侵袭性特征。与基底细胞癌的鉴别诊断可能较为困难，但免疫组织化学有助于鉴别。
这是文献中报道的首例外阴毛母细胞瘤病例。尽管它是良性肿瘤，但由于其难以与基底细胞癌区分且具有恶性转化的可能性，建议进行切缘阴性的切除手术。
