Cardiovascular Division, Hospital of the University of Pennsylvania and Cardiovascular Institute, University of Pennsylvania, 3400 Spruce Street, 9 Gates, Philadelphia, PA, 19104, USA.
Curr Atheroscler Rep. 2014 Mar;16(3):397. doi: 10.1007/s11883-014-0397-1.
The concept of the vulnerable atherosclerotic plaque first developed through histological evaluation of post-mortem coronary arteries has been significantly advanced in recent years by new imaging modalities. Imaging has: 1) verified histological findings, 2) identified features that are associated with unstable plaque, 3) followed plaques over time to study the dynamic nature of vulnerable plaque, 4) predicted clinical events based on imaging features, 5) tested the impact of medical interventions on plaque morphology. This review will summarize the major findings of imaging studies with a focus on how the knowledge base of vulnerable plaque has been advanced.
通过对死后冠状动脉的组织学评估，易损动脉粥样硬化斑块的概念近年来在新的成像方式的推动下取得了重大进展。这些成像技术：1）验证了组织学发现；2）确定了与不稳定斑块相关的特征；3）随着时间的推移对斑块进行跟踪以研究易损斑块的动态特性；4）根据成像特征预测临床事件；5）检验了医学干预对斑块形态的影响。本综述将总结影像学研究的主要发现，重点介绍易损斑块知识库的发展。
