Mesalazine-induced renal calculi.
作者信息
Jacobsson Henrik, Eriksen Jaran, Karlén Per
机构信息
Division of Medicine, Department of Clinical Sciences, Karolinska Institute, Danderyd Hospital, Stockholm, Sweden.
Division of Clinical Pharmacology, Department of Laboratory Sciences, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden.
出版信息
Am J Case Rep. 2013 Dec 23;14:551-3. doi: 10.12659/AJCR.889719. eCollection 2013.
PATIENT
Female, 32 FINAL DIAGNOSIS: Renal colic Symptoms: Acute colic pain • macrohematuria
MEDICATION
Mesalazine Clinical Procedure: CT scan of urinary tract • cystoscopy • gynecological consultation • stone analysis Specialty: Gastroenterology and Hepatology • Clinical Pharmacology.
OBJECTIVE
Unexpected drug reaction.
BACKGROUND
Mesalazine, a 5-aminosalicylic acid compound, is one of the cornerstones in modern treatment regimens of ulcerative colitis. It is generally well tolerated, although adverse reactions such as nephrotoxicity, perimyocarditis, and pancreatitis have been reported.
CASE REPORT
We report the case of a 32-year-old woman with colitis who developed recurrent episodes of renal colic after introduction of mesalazine to her treatment. Biochemical analysis of the stones showed that they were composed of crystalized drug material.
CONCLUSIONS
To our knowledge this is the first report of mesalazine precipitation in the urinary tract. We believe that it is vital for physicians to recognize this potentially severe adverse effect in the use of this treatment.
Zotero 插件