George Sophia H L, Shaw Patricia
Department of Laboratory Medicine and Pathobiology, Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, University of Toronto , Toronto, ON , Canada.
Front Oncol. 2014 Jan 23;4:5. doi: 10.3389/fonc.2014.00005. eCollection 2014.
Women who have an inherited mutation in the BRCA1 or BRCA2 genes have a substantial increased lifetime risk of developing epithelial ovarian cancer (EOC), and epidemiological factors related to parity, ovulation, and hormone regulation have a dramatic effect on the risk in both BRCA mutation carriers and non-carriers. The most common and most aggressive histotype of EOC, high-grade serous carcinoma (HGSC), is also the histotype associated with germline BRCA mutations. In recent years, evidence has emerged indicating that the likely tissue of origin of HGSC is the fallopian tube. We have reviewed, what is known about the fallopian tube in BRCA mutation carriers at both the transcriptional and translational aspect of their biology. We propose that changes of the transcriptome in BRCA heterozygotes reflect an altered response to the ovulatory stresses from the microenvironment, which may include the post-ovulation inflammatory response and altered reproductive hormone physiology.
携带BRCA1或BRCA2基因遗传突变的女性一生中患上皮性卵巢癌（EOC）的风险大幅增加，与生育、排卵及激素调节相关的流行病学因素对BRCA突变携带者和非携带者的风险均有显著影响。EOC最常见且侵袭性最强的组织学类型，即高级别浆液性癌（HGSC），也是与种系BRCA突变相关的组织学类型。近年来，有证据表明HGSC可能的组织起源是输卵管。我们从生物学的转录和翻译层面综述了关于BRCA突变携带者输卵管的已知情况。我们提出，BRCA杂合子中转录组的变化反映了对来自微环境的排卵应激的反应改变，这可能包括排卵后的炎症反应和生殖激素生理的改变。
