Keyvani Vahideh, Riahi Espanta, Yousefi Meysam, Esmaeili Seyed-Alireza, Shafabakhsh Rana, Moradi Hasan-Abad Amin, Mahjoubin-Tehran Maryam, Hamblin Michael R, Mollazadeh Samaneh, Mirzaei Hamed
Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Front Pharmacol. 2022 Feb 16;13:823572. doi: 10.3389/fphar.2022.823572. eCollection 2022.
Gynecologic cancer is one of the main causes of death in women. In this type of cancer, several molecules (oncogenes or tumor suppressor genes) contribute to the tumorigenic process, invasion, metastasis, and resistance to treatment. Based on recent evidence, the detection of molecular changes in these genes could have clinical importance for the early detection and evaluation of tumor grade, as well as the selection of targeted treatment. Researchers have recently focused on cancer stem cells (CSCs) in the treatment of gynecologic cancer because of their ability to induce progression and recurrence of malignancy. This has highlighted the importance of a better understanding of the molecular basis of CSCs. The purpose of this review is to focus on the molecular mechanism of gynecologic cancer and the role of CSCs to discover more specific therapeutic approaches to gynecologic cancer treatment.
妇科癌症是女性死亡的主要原因之一。在这类癌症中，多种分子（癌基因或肿瘤抑制基因）参与肿瘤发生过程、侵袭、转移及治疗耐药。基于近期证据，检测这些基因中的分子变化对于肿瘤早期检测、分级评估以及靶向治疗选择可能具有临床意义。由于癌症干细胞（CSCs）具有诱导恶性肿瘤进展和复发的能力，研究人员最近在妇科癌症治疗中聚焦于它们。这凸显了更好地理解癌症干细胞分子基础的重要性。本综述的目的是聚焦于妇科癌症的分子机制以及癌症干细胞的作用，以发现更具特异性的妇科癌症治疗方法。
