一种独特的来源于 1,2-二氯乙烷和 TMSN3 的“CN”组合源，用于铜催化的氮原子邻位 C(sp3)-H 键氰化反应。

A unique combined source of "CN" from 1,2-dichloroethane and TMSN3 in the copper-catalyzed cyanation of a C(sp3)-H bond adjacent to a nitrogen atom.

机构信息

School of Chemical Engineering, Nanjing University of Science, Technology , Nanjing 210000, China.

出版信息

Org Lett. 2014 Feb 7;16(3):656-9. doi: 10.1021/ol500045p. Epub 2014 Jan 30.

Abstract

A novel combined metal-free "CN" source from trimethylsilyl azide and 1,2-dichloroethane has been developed and successfully applied to copper-catalyzed oxidative cyanation of α-C-H tertiary amines for the synthesis of C1-cyanation tetrahydroisoquinoline derivatives with good to excellent yields for the first time.

摘要

一种新型的联合无金属“CN”源，由三甲基叠氮硅烷和 1,2-二氯乙烷组成，已被开发出来并成功应用于铜催化的α-C-H 叔胺的氧化氰化反应，首次以良好至优秀的收率合成了 C1-氰化四氢异喹啉衍生物。