手性金属/有机催化的、以氧气为唯一氧化剂的、三级胺的 sp3 C-H 不对称氧化烯烃化反应。
Enantioselective metal/organo-catalyzed aerobic oxidative sp3 C-H olefination of tertiary amines using molecular oxygen as the sole oxidant.
机构信息
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China.
出版信息
J Am Chem Soc. 2012 Aug 1;134(30):12334-7. doi: 10.1021/ja303333k. Epub 2012 Jul 23.
An organocatalysis/copper-catalyzed asymmetric oxidative sp(3) C-H olefination reaction of tertiary amines with olefins using molecular oxygen as the sole oxidant under mild conditions was realized for the first time. This novel strategy provides an efficient and environmentally friendly way to access diversify optically active C(1)-alkene tetrahydroisoquinoline derivatives.
首次实现了在温和条件下，以氧气为唯一氧化剂，通过有机催化/铜催化不对称氧化 sp(3) C-H 烯烃化反应，将叔胺与烯烃反应。该新策略为获得多样化的手性 C(1)-烯烃四氢异喹啉衍生物提供了一种有效且环保的方法。
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