Department of Psychology, Michigan State University, East Lansing, MI, 48824, United States.
Department of Psychology, Michigan State University, East Lansing, MI, 48824, United States.
Physiol Behav. 2014 Mar 29;127:81-6. doi: 10.1016/j.physbeh.2014.01.012. Epub 2014 Jan 28.
Binge eating is a significantly heritable phenotype, but efforts to detect specific risk genes have fallen short. Identification of animal strain differences in risk for binge eating could highlight genetic differences across individuals of the same species that can be exploited in future animal and molecular genetic research. The current study aimed to explore strain differences in risk for binge eating in Sprague-Dawley versus Wistar female rats using the Binge Eating Resistant/Binge Eating Prone model. A sample of male Sprague-Dawley rats, a known low-risk group for binge eating, was included as a comparison group. A total of 83 rats (23 Wistar females, 30 Sprague-Dawley females, 30 Sprague-Dawley males) completed a protocol of intermittently administered, palatable food. Binge eating prone (BEP) and binge eating resistant (BER) rats were identified using a tertile approach. Sprague-Dawley female rats consumed the highest amount of palatable food and were more likely to be classified as BEP compared to Wistar female and Sprague-Dawley male rats. Wistar female rats were not significantly different from Sprague-Dawley male rats in their palatable food intake and tendency to be classified as BER rather than BEP. Sprague-Dawley female rats appear to be a particularly vulnerable genotype for binge eating. Comparisons between this group and others could help identify specific genetic/biological factors that differentiate it from lower risk groups. The reward system, linked to binge eating in humans, is a possible candidate to explore. Strain differences in the reward system could help increase understanding of individual differences in risk for binge eating in humans.
暴食是一种具有显著遗传性的表型，但检测特定风险基因的努力尚未成功。识别暴食风险在动物品系之间的差异，可以突出同一物种个体之间的遗传差异，这些差异可以在未来的动物和分子遗传研究中得到利用。本研究旨在使用暴食抵抗/暴食倾向模型探索 Sprague-Dawley 与 Wistar 雌性大鼠在暴食风险方面的品系差异。还纳入了一组已知暴食风险较低的雄性 Sprague-Dawley 大鼠作为比较组。共有 83 只大鼠（23 只 Wistar 雌性大鼠、30 只 Sprague-Dawley 雌性大鼠、30 只 Sprague-Dawley 雄性大鼠）完成了间歇性给予美味食物的方案。使用三分位法确定暴食倾向（BEP）和暴食抵抗（BER）大鼠。与 Wistar 雌性和 Sprague-Dawley 雄性大鼠相比，Sprague-Dawley 雌性大鼠消耗的美味食物最多，更有可能被归类为 BEP。Wistar 雌性大鼠在美味食物摄入量和被归类为 BER 而不是 BEP 的倾向方面与 Sprague-Dawley 雄性大鼠没有显著差异。Sprague-Dawley 雌性大鼠似乎是暴食的一个特别脆弱的基因型。与其他组进行比较可以帮助确定将其与低风险组区分开来的特定遗传/生物学因素。与人类暴食相关的奖励系统是一个可能的候选对象。奖励系统的品系差异可以帮助增加对人类暴食风险个体差异的理解。
