2012年5月至8月，保加利亚两个地区由肠道病毒30型引起的无菌性脑膜炎暴发。
Aseptic meningitis outbreak caused by echovirus 30 in two regions in Bulgaria, May-August 2012.
作者信息
Mladenova Z, Buttinelli G, Dikova A, Stoyanova A, Troyancheva M, Komitova R, Stoycheva M, Pekova L, Parmakova K, Fiore L
机构信息
Department of Virology, National Center for Infectious and Parasitic Diseases, Sofia,Bulgaria.
National Centre for Immunobiologicals Research and Evaluation, Istituto Superiore di Sanità, Rome,Italy.
出版信息
Epidemiol Infect. 2014 Oct;142(10):2159-65. doi: 10.1017/S0950268813003221. Epub 2013 Dec 19.
An aseptic meningitis outbreak emerged in two regions in Bulgaria in 2012 and echovirus 30 (E30) was established as the aetiological agent by cell culture isolation, serological test, and molecular-based techniques. A total of 157 patients with aseptic meningitis were investigated, of which 117 were confirmed as having E30-associated disease. Molecular analysis of 12 E30 isolates revealed 99-100% nucleotide and amino-acid identity between them and a close correlation with a Greek strain involved in an E30 outbreak in 2012. Children aged 5-14 years were mainly affected, which could reflect the absence of E30 epidemics in Bulgaria for a period of 11 years. The first case with E30 isolation (a 2-year-old patient from Plovdiv) was notified at the end of April 2012. This was most likely the index case, from which the spread of the virus started, causing sporadic cases first, which later led to an aseptic meningitis outbreak facilitated by person-to-person viral transmission.
2012年，保加利亚的两个地区出现了无菌性脑膜炎疫情，通过细胞培养分离、血清学检测和分子技术确定肠道病毒30型（E30）为病原体。共对157例无菌性脑膜炎患者进行了调查，其中117例被确诊为患有E30相关疾病。对12株E30分离株的分子分析显示，它们之间的核苷酸和氨基酸同一性为99%-100%，且与2012年希腊一次E30疫情中涉及的毒株密切相关。主要受影响的是5-14岁的儿童，这可能反映出保加利亚在11年的时间里没有E30疫情。2012年4月底报告了首例分离出E30的病例（一名来自普罗夫迪夫的2岁患者）。这很可能是指示病例，病毒由此开始传播，首先导致散发病例，随后通过人际间病毒传播引发了无菌性脑膜炎疫情。
Zotero 插件