Plass D, Mangen M-J J, Kraemer A, Pinheiro P, Gilsdorf A, Krause G, Gibbons C L, VAN Lier A, McDONALD S A, Brooke R J, Kramarz P, Cassini A, Kretzschmar M E E
Department of Public Health Medicine, School of Public Health,University of Bielefeld,Bielefeld,Germany.
University Medical Centre Utrecht (UMCU),Utrecht,The Netherlands.
Epidemiol Infect. 2014 Oct;142(10):2024-35. doi: 10.1017/S0950268813003312. Epub 2014 Jan 2.
Setting priorities in the field of infectious diseases requires evidence-based and robust baseline estimates of disease burden. Therefore, the European Centre for Disease Prevention and Control initiated the Burden of Communicable Diseases in Europe (BCoDE) project. The project uses an incidence- and pathogen-based approach to measure the impact of both acute illness and sequelae of infectious diseases expressed in disability-adjusted life years (DALYs). This study presents first estimates of disease burden for four pathogens in Germany. The number of reported incident cases adjusted for underestimation served as model input. For the study period 2005-2007, the average disease burden was estimated at 33 116 DALYs/year for influenza virus, 19 115 DALYs/year for Salmonella spp., 8708 DALYs/year for hepatitis B virus and 740 DALYs/year for measles virus. This methodology highlights the importance of sequelae, particularly for hepatitis B and salmonellosis, because if omitted, the burden would have been underestimated by 98% and 56%, respectively.
在传染病领域确定优先事项需要基于证据且可靠的疾病负担基线估计。因此，欧洲疾病预防控制中心启动了欧洲传染病负担（BCoDE）项目。该项目采用基于发病率和病原体的方法来衡量以伤残调整生命年（DALYs）表示的急性疾病和传染病后遗症的影响。本研究给出了德国四种病原体疾病负担的初步估计。针对漏报情况调整后的报告发病病例数用作模型输入。在2005 - 2007年研究期间，流感病毒的平均疾病负担估计为每年33116伤残调整生命年，沙门氏菌属为每年19115伤残调整生命年，乙型肝炎病毒为每年8708伤残调整生命年，麻疹病毒为每年740伤残调整生命年。这种方法突出了后遗症的重要性，特别是对于乙型肝炎和沙门氏菌病而言，因为如果遗漏这些后遗症，疾病负担将分别被低估98%和56%。
