Aoyagi Y, Suzuki Y, Isemura M, Nomoto M, Sekine C, Igarashi K, Ichida F
Department of Internal Medicine, Niigata University School of Medicine, Japan.
Cancer. 1988 Feb 15;61(4):769-74. doi: 10.1002/1097-0142(19880215)61:4<769::aid-cncr2820610422>3.0.co;2-m.
The serum concentration and degree of fucosylation (fucosylation index) of alpha-fetoprotein (AFP) were determined in serum samples from 258 patients with hepatocellular carcinoma (HCC) and 114 patients with benign liver diseases. When the serum AFP concentration was below 1000 ng/ml, it could not be used as a measure to distinguish between HCC and benign liver diseases. However, the fucosylation index of AFP proved useful for such a purpose. The sensitivity of the analysis using the fucosylation index in total patients with HCC was 69%; the specificity was 96% in benign liver diseases, and the accuracy of this test was 77%. When HCC patients who were grouped according to tumor size (5 cm, 3 cm, and 2 cm in diameter) were analyzed, they all had a fucosylation index significantly higher than that in benign liver disease patients. The mean fucosylation index in 28 patients with a serum AFP concentration below 1000 ng/ml and a tumor diameter less than 3 cm was 26 +/- 30%. Corresponding values for 16 patients with an AFP concentration below 400 ng/ml and a tumor size less than 3 cm and for 8 patients with a concentration below 400 ng/ml and a tumor size less than 2 cm were 32 +/- 31% and 27 +/- 27%, respectively. These values were higher, with statistical significance, than those in patients with benign liver diseases. These data indicate that the measurement of the fucosylation index of AFP is useful for the early diagnosis of HCC.
测定了258例肝细胞癌（HCC）患者和114例良性肝病患者血清样本中甲胎蛋白（AFP）的血清浓度和岩藻糖基化程度（岩藻糖基化指数）。当血清AFP浓度低于1000 ng/ml时，它不能作为区分HCC和良性肝病的指标。然而，AFP的岩藻糖基化指数被证明可用于此目的。使用岩藻糖基化指数对所有HCC患者进行分析的敏感性为69%；在良性肝病中特异性为96%，该检测的准确性为77%。当根据肿瘤大小（直径5 cm、3 cm和2 cm）对HCC患者进行分组分析时，他们的岩藻糖基化指数均显著高于良性肝病患者。28例血清AFP浓度低于1000 ng/ml且肿瘤直径小于3 cm的患者，其平均岩藻糖基化指数为26±30%。16例AFP浓度低于400 ng/ml且肿瘤大小小于3 cm的患者以及8例浓度低于400 ng/ml且肿瘤大小小于2 cm的患者的相应值分别为32±31%和27±27%。这些值均高于良性肝病患者，具有统计学意义。这些数据表明，测定AFP的岩藻糖基化指数对HCC的早期诊断有用。
