Hryniewicz-Jankowska Anita, Augoff Katarzyna, Biernatowska Agnieszka, Podkalicka Joanna, Sikorski Aleksander F
University of Wrocław, Biotechnology Faculty, Wrocław, Poland.
Medical University of Wrocław, Department of Gastrointestinal and General Surgery, Wrocław, Poland.
Biochim Biophys Acta. 2014 Apr;1845(2):155-65. doi: 10.1016/j.bbcan.2014.01.006. Epub 2014 Jan 27.
Membrane rafts are distinct plasma membrane microdomains that are enriched in sphingolipids and cholesterol. They organize receptors and their downstream molecules and regulate a number of intracellular signaling pathways. This review presents information on the dependence of several growth factor receptor signaling pathways on membrane rafts. It also discusses the involvement of rafts in the regulation of differentiation, apoptosis and cell migration connected with invasiveness and metastasis. Examples of known synthetic and naturally occurring substances that are known to affect lateral membrane organization in tumor cell growth are discussed as potential or actual therapeutics.
膜筏是富含鞘脂和胆固醇的独特质膜微区。它们组织受体及其下游分子，并调节多种细胞内信号通路。本综述介绍了几种生长因子受体信号通路对膜筏的依赖性信息。还讨论了膜筏在与侵袭和转移相关的分化、凋亡和细胞迁移调节中的作用。作为潜在或实际的治疗方法，讨论了已知的影响肿瘤细胞生长中侧向膜组织的合成和天然物质的例子。
