Mollnes T E, Tambs K E, Myreng Y, Engebretsen L F
Institute of Immunology and Rheumatology, National Hospital, Oslo, Norway.
Complement. 1988;5(1):33-9. doi: 10.1159/000463029.
The acute phase proteins, C-reactive protein (CRP), orosomucoid, alpha 1-antitrypsin and haptoglobin, the native complement components C3 and C4, activation products of C3, and the terminal SC5b-9 complement complex were quantified in samples obtained on admittance and on days 1, 2, 3 and 6 in 21 patients with non-complicated acute myocardial infarction (AMI) and in 22 controls. For all proteins peak and median concentrations were higher in the AMI group than in the controls, but the difference was significant only for CRP and orosomucoid. Median CRP concentration was 46 mg/l in the AMI group and 2.5 in the control group. The corresponding orosomucoid concentrations were 1.6 and 1.2 g/l. There was no correlation between the concentration of CRP in peripheral blood and the degree of complement activation. Furthermore, no correlation was observed between complement activation and the size of infarction. The present study cannot demonstrate that the increased concentrations of CRP and other acute phase reactants observed in patients with AMI, are associated with systemic fluid-phase complement activation. Furthermore, the complement activation previously shown locally in infarcted myocardium cannot be demonstrated systemically in non-complicated AMI.
在21例非复杂性急性心肌梗死（AMI）患者和22例对照者中，对入院时以及第1、2、3和6天采集的样本中的急性期蛋白、C反应蛋白（CRP）、血清类黏蛋白、α1抗胰蛋白酶和触珠蛋白、天然补体成分C3和C4、C3激活产物以及终末SC5b-9补体复合物进行了定量分析。对于所有蛋白质，AMI组的峰值浓度和中位数浓度均高于对照组，但仅CRP和血清类黏蛋白的差异具有统计学意义。AMI组的CRP中位数浓度为46mg/L，对照组为2.5mg/L。相应的血清类黏蛋白浓度分别为1.6g/L和1.2g/L。外周血中CRP浓度与补体激活程度之间无相关性。此外，未观察到补体激活与梗死面积之间的相关性。本研究无法证明AMI患者中观察到的CRP和其他急性期反应物浓度升高与全身液相补体激活有关。此外，先前在梗死心肌局部显示的补体激活在非复杂性AMI中无法在全身得到证实。
