Lee Eun-Young, Eslinger Paul J, Du Guangwei, Kong Lan, Lewis Mechelle M, Huang Xuemei
Departments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
Mov Disord. 2014 Aug;29(9):1205-8. doi: 10.1002/mds.25829. Epub 2014 Jan 30.
Olfactory dysfunction is often associated with Parkinson's disease (PD) and can precede characteristic motor symptoms by several years. Olfactory-related cortical atrophy has been reported in PD, although the extent and association between cortical atrophy and olfactory dysfunction have been controversial. The present study examined whether olfactory dysfunction is associated with gray matter (GM) volume in brain regions subserving primary and secondary olfactory processing.
High-resolution T1-weighted brain MRIs were acquired from 40 PD without dementia and 40 matched controls along with smell identification scores. Brain volumes were compared using voxel-based morphometry.
Compared to controls, PD patients sustained greater GM loss localized to bilateral piriform cortex (PC) and orbitofrontal cortex (OFC). Reduced olfactory performance in PD was significantly associated with lower GM volumes in PC and OFC.
Both primary and secondary olfactory cortical atrophy occurred in PD and were associated with olfactory dysfunction.
嗅觉功能障碍常与帕金森病（PD）相关，且可在特征性运动症状出现前数年出现。虽然PD患者存在嗅觉相关皮质萎缩，但皮质萎缩与嗅觉功能障碍之间的程度及关联一直存在争议。本研究检测嗅觉功能障碍是否与参与初级和次级嗅觉处理的脑区灰质（GM）体积相关。
对40例无痴呆的PD患者和40例匹配的对照者进行高分辨率T1加权脑MRI检查，并记录嗅觉识别分数。采用基于体素的形态学测量方法比较脑体积。
与对照组相比，PD患者双侧梨状皮质（PC）和眶额皮质（OFC）出现更明显的GM丢失。PD患者嗅觉功能减退与PC和OFC中较低的GM体积显著相关。
PD患者出现初级和次级嗅觉皮质萎缩，且与嗅觉功能障碍相关。
