单侧后鼻孔闭锁：术后长期嗅觉缺陷和脑容积变化的指征。
Unilateral Choanal Atresia: Indications of Long-Term Olfactory Deficits and Volumetric Brain Changes Postsurgically.
机构信息
Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
Department of Radiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
出版信息
ORL J Otorhinolaryngol Relat Spec. 2022;84(2):89-92. doi: 10.1159/000520188. Epub 2021 Nov 26.
BACKGROUND
Very few studies have investigated whether unilateral choanal atresia is associated with permanent olfactory deficits.
OBJECTIVE
This study aimed to evaluate the olfactory performance of patients with unilateral choanal atresia postsurgically.
METHODS
Three patients with unilateral atresia were examined in terms of olfactory performance with the Sniffin' Sticks test (odor identification, threshold, and discrimination), size of the olfactory bulb, and volumetric brain changes.
RESULTS
All patients demonstrated significantly lower olfactory performance in terms of odor threshold on the same side with the choanal atresia. Grey matter reductions were found ipsilaterally in the hippocampus.
CONCLUSIONS
This pilot study indicates that persistent olfactory deficits and volumetric brain changes are present in patients with unilateral choanal atresia.
背景
很少有研究调查单侧后鼻孔闭锁是否与永久性嗅觉缺陷有关。
目的
本研究旨在评估单侧后鼻孔闭锁患者术后的嗅觉表现。
方法
使用嗅棒测试（嗅觉识别、阈值和辨别）评估 3 例单侧闭锁患者的嗅觉表现，同时评估嗅球大小和脑容积变化。
结果
所有患者在单侧后鼻孔闭锁同侧的嗅觉阈值方面表现出明显较低的嗅觉功能。在同侧的海马区发现灰质减少。
结论
这项初步研究表明，单侧后鼻孔闭锁患者存在持续性嗅觉缺陷和脑容积变化。
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