Morgan Elise F, De Giacomo Anthony, Gerstenfeld Louis C
Boston University School of Medicine, Boston, MA, USA.
Methods Mol Biol. 2014;1130:13-31. doi: 10.1007/978-1-62703-989-5_2.
The study of postnatal skeletal repair is of immense clinical interest. Optimal repair of skeletal tissue is necessary in all varieties of elective and reparative orthopedic surgical treatments. However, the repair of fractures is unique in this context in that fractures are one of the most common traumas that humans experience and are the end-point manifestation of osteoporosis, the most common chronic disease of aging. In the first part of this introduction the basic biology of fracture healing is presented. The second part discusses the primary methodological approaches that are used to examine repair of skeletal hard tissue and specific considerations for choosing among and implementing these approaches.
产后骨骼修复的研究具有极大的临床意义。在各种择期和修复性骨科手术治疗中，骨骼组织的最佳修复都是必要的。然而，骨折修复在这方面具有独特性，因为骨折是人类最常经历的创伤之一，也是骨质疏松症（最常见的衰老慢性疾病）的终末表现形式。在本引言的第一部分，介绍了骨折愈合的基本生物学原理。第二部分讨论了用于检查骨骼硬组织修复的主要方法学途径，以及在这些途径中进行选择和实施时的具体注意事项。
