Department of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
Chemistry. 2016 Dec 5;22(49):17715-17724. doi: 10.1002/chem.201602809. Epub 2016 Oct 27.
Studies on magnetoliposomes (MLUV) as potential carriers for magnetic-field-dependent drug delivery are presented. The systems were formed with hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) confined within the bilayer of the liposomes. The nanomechanical properties of bilayer lipid membranes were evaluated and related to the amount of incorporated SPIONs. It was found that the presence of SPIONs in the lipid membrane leads to overall stiffening and increases morphological inhomogeneity, facilitating rupture of the MLUV membrane in a low-frequency alternating magnetic field (AMF). To verify the findings, doxorubicin release from MLUVs in the presence and absence of an AMF was measured. Under experimental conditions, drug release proceeds through MLUV rupture induced by mechanical vibration of SPIONs rather than through localized heating in the vicinity of the SPIONs.
研究了磁脂质体（MLUV）作为磁场依赖型药物传递的潜在载体。该体系由限制在脂质体双层内的疏水性超顺磁性氧化铁纳米粒子（SPIONs）组成。评估了双层脂质膜的纳米力学性质，并将其与掺入的 SPIONs 的量相关联。结果发现，脂质膜中 SPIONs 的存在导致整体变硬，并增加形态异质性，从而在低频交变磁场（AMF）下促进 MLUV 膜破裂。为了验证这一发现，测量了在存在和不存在 AMF 的情况下 MLUV 中阿霉素的释放。在实验条件下，药物释放是通过 SPIONs 的机械振动引起的 MLUV 破裂而不是通过 SPIONs 附近的局部加热来进行的。
